Evidence map›Paper›PMID 31543547›Full record

ArticleJournal of the mechanics and physics of solids2019

Mechanobiological Stability of Biological Soft Tissues.

Marcos Latorre, Jay D Humphrey

Abstract read
In one paragraph

Article in Journal of the mechanics and physics of solids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Mechanics and mechanobiology of arterial development.Biomechanics and modeling in mechanobiology · 2026
    Review
  2. Mechanisms driving thoracic aortic aneurysm instability.Biomechanics and modeling in mechanobiology · 2026
    Article
  3. Article
  4. Mechanisms Driving Thoracic Aortic Aneurysm Stability.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. FSGe: A fast and strongly-coupled 3D fluid-solid-growth interaction method.Computer methods in applied mechanics and engineering · 2024
    Article
  9. Article
  10. Article
  11. Intracellular signaling control of mechanical homeostasis in the aorta.Biomechanics and modeling in mechanobiology · 2022
    Article
  12. Article
  13. Vascular Mechanobiology: Homeostasis, Adaptation, and Disease.Annual review of biomedical engineering · 2021
    Review
  14. Developmental origins of mechanical homeostasis in the aorta.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Article
  15. Complementary roles of mechanotransduction and inflammation in vascular homeostasis.Proceedings. Mathematical, physical, and engineering sciences · 2021
    Article
  16. [Review of studies on the biomechanical modelling of the coupling effect between stent degradation and blood vessel remodeling].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. The role of topology and mechanics in uniaxially growing cell networks.Proceedings. Mathematical, physical, and engineering sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marcos LatorreDepartment of Biomedical Engineering Yale University, New Haven, CT 06520, USA.
Jay D HumphreyDepartment of Biomedical Engineering Yale University, New Haven, CT 06520, USA.

Funding

TGFB-Dependent Mechanoresponses by Aortic Smooth Muscle Cells Govern AneurysmsP01HL134605 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RIFKIN, DANIEL B · 2018 to 2022
$12.1M
Mechanisms Underlying The Progression of Large Artery Stiffness in HypertensionR01HL105297 · NHLBI · YALE UNIVERSITY · PI FIGUEROA, CARLOS ALBERTO, HUMPHREY, JAY D. · 2010 to 2019
$3.0M
Multimodality imaging-driven multifidelity modeling of aortic dissectionU01HL142518 · NHLBI · YALE UNIVERSITY · PI HUMPHREY, JAY D., KARNIADAKIS, GEORGE · 2018 to 2022
$2.8M
Computational Model Driven Design of Tissue Engineered Vascular GraftsR01HL128602 · NHLBI · YALE UNIVERSITY · PI BREUER, CHRISTOPHER KANE, HUMPHREY, JAY D. · 2015 to 2018
$2.2M
NHLBI NIH HHS P01 HL134605NHLBI NIH HHS R01 HL105297NHLBI NIH HHS R01 HL128602NHLBI NIH HHS U01 HL142518
6 · The paper itself

Abstract

Like all other materials, biological soft tissues are subject to general laws of physics, including those governing mechanical equilibrium and stability. In addition, however, these tissues are able to respond actively to changes in their mechanical and chemical environment. There is, therefore, a pressing need to understand such processes theoretically. In this paper, we present a new rate-based constrained mixture formulation suitable for studying mechanobiological equilibrium and stability of soft tissues exposed to transient or sustained changes in material composition or applied loading. These concepts are illustrated for canonical problems in arterial mechanics, which distinguish possible stable versus unstable mechanobiological responses. Such analyses promise to yield insight into biological processes that govern both health and disease progression.

Indexed as

adaptationextracellular matrixmatrix turnovermechanical homeostasistissue growth

Identifiers

PMID31543547
PMCPMC6754118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.