Evidence map›Paper›PMID 31543506›Full record

ArticleMolecular pharmacology2019

An Interhelical Salt Bridge Controls Flexibility and Inhibitor Potency for Regulators of G-protein Signaling Proteins 4, 8, and 19.

Vincent S Shaw, Mohammadjavad Mohammadi, Josiah A Quinn, Harish Vashisth, Richard R Neubig

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vincent S ShawDepartment of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.).
Mohammadjavad MohammadiDepartment of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.).
Josiah A QuinnDepartment of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.).
Harish VashisthDepartment of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.) harish.vashisth@unh.edu.ORCID 0000-0002-2087-2880
Richard R NeubigDepartment of Pharmacology and Toxicology (V.S.S., J.A.Q., R.R.N.) and Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine (R.R.N.), Michigan State University, East Lansing, Michigan; and Department of Chemical Engineering, University of New Hampshire, Durham, New Hampshire (M.M., H.V.) rneubig@msu.edu.ORCID 0000-0003-0501-0008
University of New Hampshire · US

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI W Kelley THOMAS · 2017 to 2026
$22.8M
Integrative Training in the Pharmacological SciencesT32GM092715 · NIGMS · MICHIGAN STATE UNIVERSITY · PI NEUBIG, RICHARD R · 2011 to 2020
$1.5M
NIGMS NIH HHS P20 GM113131NIGMS NIH HHS T32 GM092715
6 · The paper itself

Abstract

Regulators of G-protein signaling (RGS) proteins modulate receptor signaling by binding to activated G-protein

Indexed as

Amino Acid SequenceProtein Structure, SecondaryRGS ProteinsThiazolidinediones4-(4-fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dioneregulator of G-protein signalling 19RGS4 proteinRGS8 protein, humanRGS ProteinsThiazolidinediones

Identifiers

PMID31543506
PMCPMC6820219
OpenAlexW2974092896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.