Evidence map›Paper›PMID 31543504›Full record

ArticleThe Journal of biological chemistry2019

The myotubularin MTMR4 regulates phagosomal phosphatidylinositol 3-phosphate turnover and phagocytosis.

David A Sheffield, Malene R Jepsen, Sandra J Feeney, Micka C Bertucci, Absorn Sriratana, Monica J Naughtin, Jennifer M Dyson, Ross L Coppel, Christina A Mitchell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

David A SheffieldMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Malene R JepsenMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Sandra J FeeneyMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Micka C BertucciMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Absorn SriratanaMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Monica J NaughtinMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Jennifer M DysonMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Ross L CoppelDepartment of Microbiology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
Christina A MitchellMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia Christina.mitchell@monash.edu.
Monash University · AUAustralian Regenerative Medicine Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophage phagocytosis is required for effective clearance of invading bacteria and other microbes. Coordinated phosphoinositide signaling is critical both for phagocytic particle engulfment and subsequent phagosomal maturation to a degradative organelle. Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a phosphoinositide that is rapidly synthesized and degraded on phagosomal membranes, where it recruits FYVE domain- and PX motif-containing proteins that promote phagosomal maturation. However, the molecular mechanisms that regulate PtdIns(3)P removal from the phagosome have remained unclear. We report here that a myotubularin PtdIns(3)P 3-phosphatase, myotubularin-related protein-4 (MTMR4), regulates macrophage phagocytosis. MTMR4 overexpression reduced and siRNA-mediated

Indexed as

PhagocytosisActinsAnimalsEndosomesHumansImmunoglobulin GLysosomesMacrophagesMiceMycobacterium marinumPhagosomesPhosphatidylinositol PhosphatesProtein Tyrosine Phosphatases, Non-ReceptorRAW 264.7 CellsReceptors, IgGRNA InterferenceActinsImmunoglobulin GMtmr4 protein, mousephosphatidylinositol 3-phosphatePhosphatidylinositol PhosphatesProtein Tyrosine Phosphatases, Non-ReceptorReceptors, IgGRNA, Small InterferingFc-gamma receptorinnate immunitymacrophagemycobacteriamyotubularin-related protein-4 (MTMR4)phagocytosisphagosomephosphatidylinositol 3-phosphate (PtdIns(3)P)phosphatidylinositol phosphatase

Identifiers

PMID31543504
PMCPMC6851315
OpenAlexW2977189426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.