Evidence map›Paper›PMID 31543434›Full record

ArticleDNA repair2019

Role of RNase H enzymes in maintaining genome stability in Escherichia coli expressing a steric-gate mutant of pol V

Erin Walsh, Sarah S Henrikus, Alexandra Vaisman, Karolina Makiela-Dzbenska, Thomas J Armstrong, Krystian Łazowski, John P McDonald, Myron F Goodman, Antoine M van Oijen, Piotr Jonczyk and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DNA repair, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Ribonucleotide incorporation into DNA during DNA replication and its consequences.Critical reviews in biochemistry and molecular biology · 2021
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Erin WalshLaboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA.
Sarah S HenrikusMolecular Horizons Institute and School of Chemistry and Biomolecular Science, University of Wollongong, Australia; Illawarra Health and Medical Research Institute, Wollongong, Australia.
Alexandra VaismanLaboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA.
Karolina Makiela-DzbenskaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Thomas J ArmstrongMolecular Horizons Institute and School of Chemistry and Biomolecular Science, University of Wollongong, Australia; Illawarra Health and Medical Research Institute, Wollongong, Australia.
Krystian ŁazowskiInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
John P McDonaldLaboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA.
Myron F GoodmanDepartments of Biological Sciences and Chemistry, University of Southern California, Los Angeles, CA 90089-2910 USA.
Antoine M van OijenMolecular Horizons Institute and School of Chemistry and Biomolecular Science, University of Wollongong, Australia; Illawarra Health and Medical Research Institute, Wollongong, Australia.
Piotr JonczykInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Iwona J FijalkowskaInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
Andrew RobinsonMolecular Horizons Institute and School of Chemistry and Biomolecular Science, University of Wollongong, Australia; Illawarra Health and Medical Research Institute, Wollongong, Australia.
Roger WoodgateLaboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-3371, USA. Electronic address: woodgate@nih.gov.
Institute of Biochemistry and Biophysics, Polish Academy of Sciences · PLNational Institutes of Health · USUniversity of Wollongong · AUIllawarra Health and Medical Research Institute · AUUniversity of Southern California · US

Funding

DNA Replication, Repair, and Mutagenesis In Eukaryotic And Prokaryotic CellsZIAHD001500 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI WOODGATE, ROGER · 2009 to 2025
$37.5M
Molecular Mechanisms of Human DNA Polymerase Beta Catalysis, Fidelity and Selective InhibitionU19CA177547 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOODMAN, MYRON · 2013 to 2017
$5.5M
Hypermutation in Bacteria and HumansR35ES028343 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GOODMAN, MYRON · 2017 to 2024
$4.3M
Intramural NIH HHS ZIA HD001500NCI NIH HHS U19 CA177547NIEHS NIH HHS R35 ES028343
6 · The paper itself

Abstract

pol V

Indexed as

DNA RepairGenomic InstabilityDNA-Directed DNA PolymeraseEscherichia coliEscherichia coli ProteinsMutationProtein DomainsRibonucleotidesDNA-Directed DNA PolymeraseDNA polymerase V, E coliEscherichia coli ProteinsRibonucleotidesDNA polymerase VRibonucleotide excision repairTranslationY-family DNA polymerase

Identifiers

PMID31543434
PMCPMC6901709
OpenAlexW2966992194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.