Evidence map›Paper›PMID 31542988›Full record

ArticleJournal of geriatric psychiatry and neurology2020

Age-Related Differences in Medication Adherence, Symptoms, and Stigma in Poorly Adherent Adults With Bipolar Disorder.

Stephen Smilowitz, Awais Aftab, Michelle Aebi, Jennifer Levin, Curtis Tatsuoka, Martha Sajatovic

Abstract read
In one paragraph

Article in Journal of geriatric psychiatry and neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephen SmilowitzDepartment of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0001-8487-4386
Awais AftabDepartment of Psychiatry, University of California San Diego, San Diego, CA, USA.
Michelle AebiDepartment of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Jennifer LevinDepartment of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Curtis TatsuokaDepartment of Neurology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Martha SajatovicDepartment of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Treatment Adherence Enhancement in Bipolar DisorderR01MH093321 · NIMH · CASE WESTERN RESERVE UNIVERSITY · PI SAJATOVIC, MARTHA X · 2012 to 2017
$2.8M
NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR002548NIMH NIH HHS R01 MH093321
6 · The paper itself

Abstract

objectiveWe present a secondary analysis of data reporting differences in medication adherence, psychiatric symptom severity, and internalized stigma levels in older (age ≥ 55 years) versus younger (age < 55 years) adults with bipolar disorder (BD) and poor medication adherence.

methodsData used for this analysis came from 184 participants in a National Institute of Mental Health-funded randomized controlled trial, comparing a customized adherence enhancement (CAE) intervention intended to promote BD medication adherence with a BD-specific educational program (EDU). At screen, study participants were ≥20% nonadherent with BD medications as measured by the Tablets Routine Questionnaire (TRQ). Psychiatric symptoms, functional status, and internalized stigma were measured using validated scales.

resultsOlder adults had significantly lower anxiety disorder comorbidity (

conclusionsOlder adults may be less anxious and depressed, with less self-stigma, compared to younger people with BD and poor adherence. With respect to medication adherence, older individuals in EDU appear to do less well than younger individuals over time.

Indexed as

AdultAge FactorsBipolar DisorderFemaleHumansMaleMedication AdherenceMiddle AgedProspective Studiesage groupsbipolar disordermedication adherencestigma

Identifiers

PMID31542988
PMCPMC7286107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.