Evidence map›Paper›PMID 31542964›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Increased Vascular Contractility in Hypertension Results From Impaired Endothelial Calcium Signaling.

Calum Wilson, Xun Zhang, Charlotte Buckley, Helen R Heathcote, Matthew D Lee, John G McCarron

Open access · greenAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Endocan as a marker of endothelial dysfunction in hypertension: a systematic review and meta-analysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
  4. The role of IPPflugers Archiv : European journal of physiology · 2026
    Review
  5. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  6. Gas entrapping materials for damage control.Advanced drug delivery reviews · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. The machinery of healthy vasoconstriction: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  11. Article
  12. Article
  13. Epigenomics and transcriptomics association study of blood pressure and incident diagnosis of hypertension in twins.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  14. Article
  15. Article
  16. CaInflammation and regeneration · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Calum WilsonFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Xun ZhangFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Charlotte BuckleyFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Helen R HeathcoteFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
Matthew D LeeFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
John G McCarronFrom the Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.
University of Strathclyde · GB

Funding

British Heart Foundation PG/16/54/32230British Heart Foundation PG/16/82/32439
6 · The paper itself

Abstract

Endothelial cells line all blood vessels and are critical regulators of vascular tone. In hypertension, disruption of endothelial function alters the release of endothelial-derived vasoactive factors and results in increased vascular tone. Although the release of endothelial-derived vasodilators occurs in a Ca

Indexed as

AnimalsCalcium SignalingDisease Models, AnimalEndothelial CellsEndothelium, VascularHypertensionMaleMembrane PotentialsMuscle, Smooth, VascularPhenylephrineRandom AllocationRatsRats, Inbred SHRRats, Inbred WKYReceptors, Calcium-SensingReference ValuesPhenylephrineReceptors, Calcium-Sensingblood pressurecalciumendothelial cellshypertensionphenylephrine

Identifiers

PMID31542964
PMCPMC6791503
OpenAlexW2976094866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.