Evidence map›Paper›PMID 31542776›Full record

ArticleTobacco control2020

Effect of electric heating and ice added to the bowl on mainstream waterpipe semivolatile furan and other toxicant yields.

Marielle C Brinkman, Andreas A Teferra, Noura O Kassem, Nada Of Kassem

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Tobacco control, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Waterpipe Size Matters: The Effect of Waterpipe Size on Toxicant Exposures and Subjective Experiences.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Trial
  2. Article
  3. Chemical Constituents and Particle Size Distribution of Mainstream Emission From Electronic Waterpipe.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  4. Review
  5. Toxicity of waterpipe tobacco smoking: the role of flavors, sweeteners, humectants, and charcoal.Toxicological sciences : an official journal of the Society of Toxicology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Marielle C BrinkmanCollege of Public Health, The Ohio State University, Columbus, Ohio, USA brinkman.224@osu.edu.ORCID 0000-0002-4315-649X
Andreas A TeferraCollege of Public Health, The Ohio State University, Columbus, Ohio, USA.
Noura O KassemSchool of Public Health, San Diego State University, San Diego, California, USA.
Nada Of KassemSchool of Public Health, San Diego State University, San Diego, California, USA.
San Diego State University · USThe Ohio State University · US

Funding

Assessing Toxicity of Waterpipe Tobacco Smoking in Laboratory and Naturalistic SettingsR01DA042471 · NIDA · SAN DIEGO STATE UNIVERSITY · PI KASSEM, NADA OSMAN · 2016 to 2018
$1.4M
NIDA NIH HHS R01 DA042471
6 · The paper itself

Abstract

objectivesWe examined mainstream total particulate matter, nicotine, cotinine, menthol, pyrene, carbon monoxide (CO) and semivolatile furan yields from a commercial waterpipe with two methods for heating the tobacco, quick-light charcoal (charcoal) and electric head (electric) and two water bowl preparations: with (ice) and without ice (water).

methodsEmissions from a single brand of popular waterpipe tobacco (10 g) were generated using machine smoking according to a two-stage puffing regimen developed from human puffing topography. Tobacco and charcoal consumption were calculated for each machine smoking session as mass lost, expressed as a fraction of presmoking mass.

resultsThe heating method had the greatest effect on toxicant yields. Electric heating resulted in increases in the fraction of tobacco consumed (2.4 times more, p<0.0001), mainstream nicotine (1.4 times higher, p=0.002) and semivolatile furan yields (1.4 times higher, p<0.03), and a decrease in mainstream CO and pyrene yields (8.2 and 2.1 times lower, respectively, p<0.001) as compared with charcoal. Adding ice to the bowl resulted in higher furan yields for electric heating. Menthol yields were not different across the four conditions and averaged 0.16±0.03 mg/session. 2-Furaldehyde and 5-(hydroxymethyl)-2-furaldehyde yields were up to 230 and 3900 times higher, respectively, than those reported for cigarettes.

conclusionWaterpipe components used to heat the tobacco and water bowl preparation can significantly affect mainstream toxicant yields. Mainstream waterpipe tobacco smoke is a significant source of inhalation exposure to semivolatile furans with human carcinogenic and mutagenic potential. These data highlight the need for acute and chronic inhalation toxicity data for semivolatile furans and provide support for the establishment of limits governing sugar additives in waterpipe tobacco and educational campaigns linking waterpipe tobacco smoking behaviours with their associated harm.

Indexed as

Smoking Water PipesCarcinogensFuransHot TemperatureHumansIceParticulate MatterSmokeTobacco, WaterpipeWater Pipe SmokingCarcinogensFuransIceParticulate MatterSmokeaddictioncarcinogensnicotinenon-cigarette tobacco products

Identifiers

PMID31542776
PMCPMC7050391
OpenAlexW2973995508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.