Evidence map›Paper›PMID 31542417›Full record

ReviewJournal of pharmaceutical and biomedical analysis2020

Clinical and pharmaceutical applications of affinity ligands in capillary electrophoresis: A review.

Chenhua Zhang, Ashley G Woolfork, Kyungah Suh, Susan Ovbude, Cong Bi, Marawan Elzoeiry, David S Hage

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pharmaceutical and biomedical analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Recent (2018-2020) development in capillary electrophoresis.Analytical and bioanalytical chemistry · 2022
    Review
  9. Label-free methods for opticalPhysical chemistry chemical physics : PCCP · 2021
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chenhua ZhangDepartment of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304, USA.
Ashley G WoolforkDepartment of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304, USA.
Kyungah SuhDepartment of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304, USA.
Susan OvbudeDepartment of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304, USA.
Cong BiDepartment of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304, USA.
Marawan ElzoeiryDepartment of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304, USA.
David S HageDepartment of Chemistry, University of Nebraska, Lincoln, NE, 68588-0304, USA. Electronic address: dhage1@unl.edu.

Funding

CHROMATOGRAPHIC AUTOMATION OF IMMUNOASSAYSR01GM044931 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI HAGE, DAVID S · 1998 to 2014
$2.7M
CHROMATOGRAPHIC STUDIES OF FUNCTIONAL PROTEOMICSR01DK069629 · NIDDK · UNIVERSITY OF NEBRASKA LINCOLN · PI HAGE, DAVID S · 2006 to 2017
$1.8M
NIDDK NIH HHS R01 DK069629NIGMS NIH HHS R01 GM044931
6 · The paper itself

Abstract

Affinity capillary electrophoresis (ACE) is a separation technique that combines a biologically-related binding agent with the separating power and efficiency of capillary electrophoresis. This review will examine several classes of binding agents that have been used in ACE and applications that have been described for the resulting methods in clinical or pharmaceutical analysis. Binding agents that will be considered are antibodies, aptamers, lectins, serum proteins, carbohydrates, and enzymes. This review will also describe the various formats in which each type of binding agent has been used in CE, including both homogeneous and heterogeneous methods. Specific areas of applications that will be considered are CE-based immunoassays, glycoprotein/glycan separations, chiral separations, and biointeraction studies. The general principles and formats of ACE for each of these applications will be examined, along with the potential advantages or limitations of these methods.

Indexed as

Chemistry, PharmaceuticalElectrophoresis, CapillaryHumansImmunoassayLigandsLigandsAffinity capillary electrophoresisBiointeraction studiesCE immunoassayChiral separationsEnzyme assays

Identifiers

PMID31542417
PMCPMC6873927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.