ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2020
Distinct Processing of Aversive Experience in Amygdala Subregions.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Effect of Tryptophan Depletion on Conditioned Threat Memory Expression: Role of Intolerance of Uncertainty.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Trial
- Dynamic changes in amygdala and insula responses to the onset and offset of conditioned stimuli during threat learning.Scientific reports · 2026Article
- Nociceptin/orphanin FQ receptor agonism attenuates behavioral and neural responses to conditioned aversive stimuli.Translational psychiatry · 2026Article
- Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence.Biological psychiatry global open science · 2025Article
- Trait anxiety is associated with reduced reward-related replay at rest.Nature communications · 2025Article
- Consumption of dietary emulsifiers increases sensitivity to social stress in mice: A potential role for the COX molecular pathway.Hormones and behavior · 2025Article
- What's the harm? Examining police contact and amygdala reactivity among black adolescents.Social cognitive and affective neuroscience · 2025Article
- Understanding the interplay between stress, anxiety, and depression and their impact on health in traffic police officers.Frontiers in psychiatry · 2025Article
- Article
- Trait-anxiety and glial-related neuroinflammation of the amygdala and its associated regions in Alzheimer's disease: A significant correlation.Brain, behavior, & immunity - health · 2024Article
- Longitudinal development of resting-state functional connectivity in adolescents with and without internalizing disorders.Neuroscience applied · 2024Article
- Rats respond to aversive emotional arousal of human handlers with the activation of the basolateral and central amygdala.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Temporally and anatomically specific contributions of the human amygdala to threat and safety learning.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- ACC-BLA functional connectivity disruption in allergic inflammation is associated with anxiety.Scientific reports · 2022Article
- Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022Review
- Robust BOLD Responses to Faces But Not to Conditioned Threat: Challenging the Amygdala's Reputation in Human Fear and Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Roles of Basolateral Amygdala Parvalbumin Neurons in Fear Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Trait anxiety predicts amygdalar responses during direct processing of threat-related pictures.Scientific reports · 2021Article
- Importance of test-retest reliability for promoting fMRI based screening and interventions in major depressive disorder.Translational psychiatry · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe amygdala is an anatomically complex medial temporal brain structure whose subregions are considered to serve distinct functions. However, their precise role in mediating human aversive experience remains ill understood.
methodsWe used functional magnetic resonance imaging in 39 healthy volunteers with varying levels of trait anxiety to assess distinct contributions of the basolateral amygdala (BLA) and centromedial amygdala to anticipation and experience of aversive events. Additionally, we examined the relationship between any identified functional subspecialization and measures of subjective reported aversion and trait anxiety.
resultsOur results show that the centromedial amygdala is responsive to aversive outcomes but insensitive to predictive aversive cues. In contrast, the BLA encodes an aversive prediction error that quantifies whether cues and outcomes are worse than expected. A neural representation within the BLA for distinct threat levels was mirrored in self-reported subjective anxiety across individuals. Furthermore, high trait-anxious individuals were characterized by indiscriminately heightened BLA activity in response to aversive cues, regardless of actual threat level.
conclusionsOur results demonstrate that amygdala subregions are distinctly engaged in processing of aversive experience, with elevated and undifferentiated BLA responses to threat emerging as a potential neurobiological mediator of vulnerability to anxiety disorders.
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