ReviewNeurobiology of learning and memory2019
Changes in cerebellar intrinsic neuronal excitability and synaptic plasticity result from eyeblink conditioning.
Review in Neurobiology of learning and memory, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Unveiling the upper-limb functional recovery mechanisms in stroke patients using brain-machine interfaces: a near-infrared functional imaging-based study.Scientific reports · 2025Trial
- The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning.Biology · 2024Review
- Pre-ataxic loss of intrinsic plasticity and motor learning in a mouse model of SCA1.Brain : a journal of neurology · 2023Article
- Thiamine Deficiency Increases Intrinsic Excitability of Mouse Cerebellar Purkinje Cells.Cerebellum (London, England) · 2021Article
- Disruption of rat deep cerebellar perineuronal net alters eyeblink conditioning and neuronal electrophysiology.Neurobiology of learning and memory · 2021Article
- Intrinsic Excitability Increase in Cerebellar Purkinje Cells after Delay Eye-Blink Conditioning in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.PLoS biology · 2020Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
There is a long history of research documenting plasticity in the cerebellum as well as the role of the cerebellum in learning and memory. Recordings in slices of cerebellum have provided evidence of long-term depression and long-term potentiation at several excitatory and inhibitory synapses. Lesions and recordings show the cerebellum is crucial for eyeblink conditioning and it appears changes in both synaptic and membrane plasticity are involved. In addition to its role in fine motor control, there is growing consensus that the cerebellum is crucial for perceptual, cognitive, and emotional functions. In the current review, we explore the evidence that eyeblink conditioning results in significant changes in intrinsic membrane excitability as well as synaptic plasticity in Purkinje cells of the cerebellar cortex in rabbits and changes in intrinsic membrane excitability in principal neurons of the deep cerebellar nuclei in rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.