ReviewFrontiers in neuroendocrinology2019
Neuroendocrine pathways underlying risk and resilience to PTSD in women.
Review in Frontiers in neuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.Nature genetics · 2024Pooled it
- Neurobiological Alterations in Females With PTSD: A Systematic Review.Frontiers in psychiatry · 2022Pooled it
- DNA methylation GrimAge acceleration in US military veterans with PTSD.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Accelerated forgetting of a trauma-like event in healthy men and women after a single dose of hydrocortisone.Translational psychiatry · 2022Trial
- Investigation of the effects of two exercise protocols on behavioral and biochemical changes in ovariectomized rats exposed to single prolonged stress.IBRO neuroscience reports · 2026Article
- Long-term impact of stressful life events on breast cancer risk: A 36-year genetically informed prospective study in the Finnish Twin Cohort.International journal of cancer · 2026Article
- Personalized resilience: how individual variability in brain-immune responses to stress influences the development of anxiety disorders.Frontiers in cellular neuroscience · 2026Review
- Longitudinal effects of pregnancy on PTSD symptoms in black female participants: Moderation by sexual trauma and progesterone.Psychoneuroendocrinology · 2025Article
- Measuring symptoms of post-traumatic stress disorder in Lebanon: psychometric validation of the Arabic version of the Impact of Event Scale-6 (IES-6).Discover mental health · 2025Article
- Sex-dependent role of hippocampal BDNF and GSK-3β in mediating PTSD-like behaviors in both sexes of adolescent rats exposed to fear conditioning, extinction, and reinstatement.Experimental brain research · 2025Article
- Merkel cell stimulation in fear and sensory signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- A systematic review on the bidirectional relationship between trauma-related psychopathology and reproductive aging.Journal of mood and anxiety disorders · 2024Article
- Conceptualizing disparities and differences in the psychobiology of traumatic stress.Journal of traumatic stress · 2024Review
- Activation of GPER1 by G1 prevents PTSD-like behaviors in mice: Illustrating the mechanisms from BDNF/TrkB to mitochondria and synaptic connection.CNS neuroscience & therapeutics · 2024Article
- Disentangling sex differences in PTSD risk factors.Nature. Mental health · 2024Article
- Sex and gender considerations in cross-cultural traumatic stress studies.European journal of psychotraumatology · 2024Article
- Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Trauma-related moderators of associations between sex hormones and PTSD symptoms: a replication-extension.European journal of psychotraumatology · 2024Article
- Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys.Biology of sex differences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Women are twice as likely than men to suffer from posttraumatic stress disorder (PTSD). While women have increased exposure to traumatic events of many types and have greater prevalence of comorbid psychiatric disorders compared to men, these differences do not account for the overall sex difference in the prevalence of PTSD. The current review summarizes significant findings that implicate the role of estradiol, progesterone, and allopregnanolone in female risk for PTSD symptoms and dysregulation of fear psychophysiology that is cardinal to PTSD. We also discuss how these steroid hormones influence the stress axis and neural substrates critical for the regulation of fear responses. Understanding the role of ovarian steroid hormones in risk and resilience for trauma-related adverse mental health outcomes across the lifespan in women has important translational, clinical, and intergenerational implications for mitigating the consequences of trauma exposure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.