Evidence map›Paper›PMID 31542245›Full record

Trial reportClinical nutrition (Edinburgh, Scotland)2020

Genetic susceptibility, lifestyle intervention and glycemic changes among women with prior gestational diabetes.

Zhaoxia Liang, Leishen Wang, Huikun Liu, Yuhang Chen, Tao Zhou, Yoriko Heianza, Junhong Leng, Weiqin Li, Xilin Yang, Yun Shen and 3 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical nutrition (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01554358 (Lifestyle and Genetic Factors on Diabetes Risk in Women With GDM After Delivery), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01554358 naunknown statusnot on this map

Lifestyle and Genetic Factors on Diabetes Risk in Women With GDM After Delivery: Tianjin Gestational Diabetes Prevention Program (TGDPP)

TypeinterventionalSponsorTianjin Women and Children's Health CenterRan2009Enrolled2,526ConditionsGestational Diabetes Mellitus (GDM)ArmsLifestyle intervention
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. TheFrontiers in endocrinology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Zhaoxia LiangDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA; Department of Obstetrical, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
Leishen WangTianjin Women's and Children's Health Center, Tianjin, China.
Huikun LiuTianjin Women's and Children's Health Center, Tianjin, China.
Yuhang ChenDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA; Department of Public Health Laboratory Sciences, West China School of Public Health, Sichuan University, Chengdu, Sichuan Province, China.
Tao ZhouDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Yoriko HeianzaDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Junhong LengTianjin Women's and Children's Health Center, Tianjin, China.
Weiqin LiTianjin Women's and Children's Health Center, Tianjin, China.
Xilin YangDepartment of Epidemiology, School of Public Health, Tianjin Medical University, Tianjin, China.
Yun ShenPennington Biomedical Research Center, Baton Rouge, LA, USA; Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai, China.
Ru GaoPennington Biomedical Research Center, Baton Rouge, LA, USA.
Gang HuPennington Biomedical Research Center, Baton Rouge, LA, USA.
Lu QiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: lqi1@tulane.edu.
Tulane University · USTianjin Children's Hospital · CNPennington Biomedical Research Center · USTianjin Medical University · CN

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Transgenics CoreP30GM118430 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2016 to 2020
$5.8M
Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet InterventionsR01DK115679 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Lu Qi · 2018 to 2026
$5.3M
Common Genetic Variation and Quantitative Diabetes TraitsR01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2008 to 2014
$5.0M
Genetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9M
Obesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5M
Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut MicrobiotaR01DK100383 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2014 to 2024
$4.2M
TOPMed Omics of Type 2 Diabetes and Quantitative TraitsUM1DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNING, ALISA KNODLE · 2021 to 2025
$3.8M
Rare Sequence Variation and Diabetes Quantitative TraitsU01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2015 to 2019
$3.6M
Methylomics of prenatal GDM: Natural history & lifestyle intervention in childrenR01DK100790 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BACCARELLI, ANDREA, HOU, LIFANG · 2014 to 2017
$2.6M
FIC NIH HHS R21 TW010790NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R21 HL126024NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK100383NIDDK NIH HHS R01 DK100790NIDDK NIH HHS R01 DK115679NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616NIGMS NIH HHS P30 GM118430NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

aimsWomen with prior gestational diabetes mellitus (GDM) or high genetic susceptibility are prone to development of type 2 diabetes. We examined whether a lifestyle intervention modified the genetic effect on changes in glycemic markers among women with prior GDM. RESEARCH DESIGN AND

methodsThis study included 560 women with prior GDM from a randomized controlled trial, the Tianjin Gestational Diabetes Mellitus Prevention Program, who were assigned into an intervention arm (improved physical activity and healthy dietary intakes) or a control arm. We assessed associations of GDM related genetic variants in/near the CDKAL1 (rs7754840) and MTNR1B (rs10830962) genes with changes in fasting levels of glucose and insulin, β-cell function (HOMA-B) and insulin resistance (HOMA-IR) at 1 year and 2 years after the baseline.

resultsWe found significant interactions between CDKAL1 variant rs7754840 and lifestyle intervention on changes in fasting insulin and HOMA-IR at 1 year (P for interactions = 0.008 and 0.006, respectively). The GDM-increasing C allele was associated with a 0.07-unit greater increase in fasting insulin (P = 0.048) and HOMA-IR (P = 0.045) in the control group, while opposite-directional associations were observed in the intervention group; women with the C allele seemed to decrease more in these glycemic markers than the non-C-carriers (both P ≤ 0.06). The interactions between the CDKAL1 genetic variant and lifestyle intervention on changes in fasting insulin (P = 0.035) and HOMA-IR (P = 0.024) remained significant over the 2-year period, even though the effects of lifestyle intervention were attenuated at 2-year. The MTNR1B variant rs10830962 did not show interaction with lifestyle intervention on changes in the glycemic markers.

conclusionsHealthy lifestyle intervention may be beneficial for women with the GDM predisposing CDKAL1 genetic variant in improvement of insulin resistance. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov NCT01554358. URL OF REGISTRATION: https://clinicaltrials.gov/ct2/show/NCT01554358.

Indexed as

Healthy LifestyleRisk Reduction BehaviorAdultBiomarkersBlood GlucoseChinaDiabetes, GestationalDiabetes Mellitus, Type 2Diet, HealthyExerciseFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansInsulinInsulin ResistanceBiomarkersBlood GlucoseCDKAL1 protein, humanInsulinMTNR1B protein, humanReceptor, Melatonin, MT2tRNA MethyltransferasesCDKAL1Gene-lifestyle interactionGestational diabetes mellitusInsulin resistanceLifestyle interventionMTNR1B

Identifiers

PMID31542245
PMCPMC7062571
OpenAlexW2972827549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.