ArticleBiophysical journal2019
Gangliosides Destabilize Lipid Phase Separation in Multicomponent Membranes.
Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 16 citations in OpenAlex.
- Hydrophobic mismatch drives self-organization of designer proteins into synthetic membranes.Nature communications · 2024Article
- The impact of the glycan headgroup on the nanoscopic segregation of gangliosides.Biophysical journal · 2021Article
- Glycocalyx Curving the Membrane: Forces Emerging from the Cell Exterior.Annual review of cell and developmental biology · 2021Review
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gangliosides (GMs) form an important class of lipids found in the outer leaflet of the plasma membrane. Typically, they colocalize with cholesterol and sphingomyelin in ordered membrane domains. However, detailed understanding of the lateral organization of GM-rich membranes is still lacking. To gain molecular insight, we performed molecular dynamics simulations of GMs in model membranes composed of coexisting liquid-ordered and liquid-disordered domains. We found that GMs indeed have a preference to partition into the ordered domains. At higher concentrations (>10 mol %), we observed a destabilizing effect of GMs on the phase coexistence. Further simulations with modified GMs show that the structure of the GM headgroup affects the phase separation, whereas the nature of the tail determines the preferential location. Together, our findings provide a molecular basis to understand the lateral organization of GM-rich membranes.
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Registered trials
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