ArticleBiological psychiatry2019
The Relationship Between the Uncinate Fasciculus and Anxious Temperament Is Evolutionarily Conserved and Sexually Dimorphic.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 24 citations in OpenAlex.
- A Neurodevelopmental Model of Social Threat Sensitivity as a Mechanism Linking Fearful Temperament, Social Anxiety, and Depression in Youth.Journal of child and adolescent psychopharmacology · 2026Review
- The Development of Trait Anxiety in Nonhuman Primates During the First Year of Life.Developmental science · 2026Article
- Healthy dietary patterns for prevention of neuropsychiatric disorders: role of inflammatory and metabolic mechanisms.NPJ science of food · 2025Article
- Insights into the Neurobiology of Behavioral Inhibition from Nonhuman Primate Models.Current topics in behavioral neurosciences · 2025Review
- Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings.Brain structure & function · 2024Review
- Early life adversity in primates: Behavioral, endocrine, and neural effects.Psychoneuroendocrinology · 2024Article
- Sex-Specific Distributed White Matter Microarchitectural Alterations in Preadolescent Youths With Anxiety Disorders: A Mega-Analytic Study.The American journal of psychiatry · 2024Article
- A preliminary study of the effects of an antimuscarinic agent on anxious behaviors and white matter microarchitecture in nonhuman primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Prefrontal influences on the function of the neural circuitry underlying anxious temperament in primates.Oxford open neuroscience · 2023Article
- Anxiety symptoms and puberty interactively predict lower cingulum microstructure in preadolescent Latina girls.Scientific reports · 2022Article
- Longitudinal assessment of early-life white matter development with quantitative relaxometry in nonhuman primates.NeuroImage · 2022Article
- A dynamic relation between whole-brain white matter microstructural integrity and anxiety symptoms in preadolescent females with pathological anxiety.Translational psychiatry · 2022Article
- MRI-Based Radiomic Machine-Learning Model May Accurately Distinguish between Subjects with Internet Gaming Disorder and Healthy Controls.Brain sciences · 2021Article
- Evidence in primates supporting the use of chemogenetics for the treatment of human refractory neuropsychiatric disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Nonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety.Biological psychiatry · 2021Review
- Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata.NeuroImage · 2021Article
- Amygdala Allostasis and Early Life Adversity: Considering Excitotoxicity and Inescapability in the Sequelae of Stress.Frontiers in human neuroscience · 2021Article
- Cortico-Limbic Interactions Mediate Adaptive and Maladaptive Responses Relevant to Psychopathology.The American journal of psychiatry · 2019Review
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5 authors at 2 institutions in 1 country.
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Abstract
backgroundAnxious temperament (AT) is an early-life heritable trait that predisposes individuals to develop anxiety and depressive disorders. Our previous work in preadolescent children suggests alterations in the uncinate fasciculus (UF), the white matter tract that connects prefrontal with limbic regions, in boys with anxiety disorders. Here, using a nonhuman primate model of AT, we tested whether this sexually dimorphic finding is evolutionarily conserved and examined the extent to which heritable and environmental influences contribute to UF microstructure.
methodsDiffusion tensor images were collected in 581 young rhesus monkeys (1.89 ± 0.77 years old; 43.9% female). Using tract-based analyses, we assessed the relationship among AT, UF microstructure (as measured with fractional anisotropy), and sex. Heritability of tract microstructure was determined using oligogenic linkage analysis of this large multigenerational pedigree.
resultsWe predicted and found a negative relation between AT and UF fractional anisotropy in male but not female monkeys (AT × sex; p = .032, 1-tailed). Additionally, heritability analyses revealed that variation in UF fractional anisotropy was largely due to nonheritable factors (h
conclusionsThese results demonstrate a cross-species, male-specific relation between UF microstructure and anxiety and provide a potential substrate for anxiety-related prefrontal-limbic dysregulation. The heritability analyses point to the importance of environmental influences on UF microstructure, which could be important in mediating the nonheritable components of pathological anxiety. These findings have the potential to guide new treatment strategies for childhood anxiety disorders and further support the use of nonhuman primates as a translational model to discover mechanisms underlying the development of anxiety.
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