Evidence map›Paper›PMID 31541920›Full record

ArticleiScience2019

An Algorithmic Information Calculus for Causal Discovery and Reprogramming Systems.

Hector Zenil, Narsis A Kiani, Francesco Marabita, Yue Deng, Szabolcs Elias, Angelika Schmidt, Gordon Ball, Jesper Tegnér

Abstract read
In one paragraph

Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
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  5. Review
  6. Article
  7. Article
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  11. Article
  12. Review
  13. Exploring Simplicity Bias in 1D Dynamical Systems.Entropy (Basel, Switzerland) · 2024
    Article
  14. Article
  15. Downward-Growing Neural Networks.Entropy (Basel, Switzerland) · 2023
    Article
  16. Auxiliary Graph for Attribute Graph Clustering.Entropy (Basel, Switzerland) · 2022
    Article
  17. Article
  18. Review
  19. Emergence and algorithmic information dynamics of systems and observers.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hector ZenilAlgorithmic Dynamics Lab, Center for Molecular Medicine, Karolinska Institutet, Stockholm 171 76, Sweden; Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm 171 76, Sweden; Oxford Immune Algorithmics, Reading RG1 3EU, UK; Science for Life Laboratory, Solna 171 65, Sweden; Algorithmic Nature Group, LABORES for the Natural and Digital Sciences, Paris 75006, France. Electronic address: hector.zenil@algorithmicnaturelab.org.
Narsis A KianiAlgorithmic Dynamics Lab, Center for Molecular Medicine, Karolinska Institutet, Stockholm 171 76, Sweden; Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm 171 76, Sweden; Science for Life Laboratory, Solna 171 65, Sweden; Algorithmic Nature Group, LABORES for the Natural and Digital Sciences, Paris 75006, France.
Francesco MarabitaUnit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm 171 76, Sweden; Science for Life Laboratory, Solna 171 65, Sweden.
Yue DengUnit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm 171 76, Sweden.
Szabolcs EliasUnit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm 171 76, Sweden; Science for Life Laboratory, Solna 171 65, Sweden.
Angelika SchmidtUnit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm 171 76, Sweden; Science for Life Laboratory, Solna 171 65, Sweden.
Gordon BallUnit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm 171 76, Sweden; Science for Life Laboratory, Solna 171 65, Sweden.
Jesper TegnérUnit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Stockholm 171 76, Sweden; Science for Life Laboratory, Solna 171 65, Sweden; Biological and Environmental Sciences and Engineering Division, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We introduce and develop a method that demonstrates that the algorithmic information content of a system can be used as a steering handle in the dynamical phase space, thus affording an avenue for controlling and reprogramming systems. The method consists of applying a series of controlled interventions to a networked system while estimating how the algorithmic information content is affected. We demonstrate the method by reconstructing the phase space and their generative rules of some discrete dynamical systems (cellular automata) serving as controlled case studies. Next, the model-based interventional or causal calculus is evaluated and validated using (1) a huge large set of small graphs, (2) a number of larger networks with different topologies, and finally (3) biological networks derived from a widely studied and validated genetic network (E. coli) as well as on a significant number of differentiating (Th17) and differentiated human cells from a curated biological network data.

Indexed as

AlgorithmsComplex SystemsComputer ScienceGene NetworkSystems Biology

Identifiers

PMID31541920
PMCPMC6831824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.