ArticleJournal of the American Academy of Child and Adolescent Psychiatry2020
Face Emotion Processing in Pediatric Irritability: Neural Mechanisms in a Sample Enriched for Irritability With Autism Spectrum Disorder.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Predictors of irritability in pediatric autistic populations: a scoping review.Frontiers in child and adolescent psychiatry · 2024Pooled it
- Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Pooled it
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- SHAP-based explainable machine learning analysis of reward-related neural connectivity to predict preadolescent irritability.Neuroimage. Reports · 2026Article
- Mediating Impact of Intranasal Oxytocin on the Interaction Between Irritability and Reactive Aggression in Youth with Severe Irritability.Life (Basel, Switzerland) · 2025Article
- An investigation of the neural basis of anger attributions in irritable youth.Emotion (Washington, D.C.) · 2024Article
- Neural correlates of peer evaluation in irritable adolescents: Linking anticipation to receipt of social feedback.Biological psychology · 2023Article
- Mediating effect of amygdala activity on response to fear vs. happiness in youth with significant levels of irritability and disruptive mood and behavior disorders.Frontiers in behavioral neuroscience · 2023Review
- Cerebral blood flow characteristics of drug-naïve attention-deficit/hyperactivity disorder with social impairment: Evidence for region-symptom specificity.Frontiers in neuroscience · 2023Article
- Amygdala-prefrontal connectivity in children with maladaptive aggression is modulated by social impairment.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling.Molecular psychiatry · 2022Article
- Linking irritability and functional brain networks: A transdiagnostic case for expanding consideration of development and environment in RDoC.Neuroscience and biobehavioral reviews · 2021Review
- Reward-related neural correlates in adolescents with excess body weight.NeuroImage. Clinical · 2021Article
- Editorial: A Transdiagnostic Symptom Requires a Transdiagnostic Approach: Neural Mechanisms of Pediatric Irritability.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Article
- Neural and behavioral correlates of inhibitory control in youths with varying levels of irritability.Journal of affective disorders · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveCharacterizing the pathophysiology of irritability symptoms from a dimensional perspective above and beyond diagnostic boundaries is key to developing mechanism-based interventions that can be applied broadly. Face emotion processing deficits are present in youths with elevated levels of irritability. The present study aimed to identify the neural mechanisms of face emotion processing in a sample enriched for irritability by including youths with high-functioning autism spectrum disorder (HF-ASD).
methodYouths (N = 120, age = 8.3-19.2 years) completed an implicit face emotion task during functional magnetic resonance imaging. We evaluated how irritability, measured dimensionally, above and beyond diagnostic group, relates to whole-brain neural activation and amygdala connectivity in response to face emotions.
resultsBoth neural activation and amygdala connectivity differed as a function of irritability level and face emotion in the prefrontal cortex. Youths with higher irritability levels had decreased activation in response to both fearful and happy faces in the left middle frontal gyrus and to happy faces in the left inferior frontal gyrus. Furthermore, increased irritability levels were associated with altered right amygdala connectivity to the left superior frontal gyrus when viewing fearful and sad faces.
conclusionThe neural mechanisms of face emotion processing differ in youths with higher irritability compared to their less irritable peers. The findings suggest that these irritability mechanisms may be common to both typically developing and HF-ASD youths. Understanding the neural mechanisms of pediatric irritability symptoms that cut across diagnostic boundaries may be leveraged for future intervention development.
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