ReviewOral diseases2020
Can oral health and oral-derived biospecimens predict progression of dementia?
Review in Oral diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Periodontal health, cognitive decline, and dementia: A systematic review and meta-analysis of longitudinal studies.Journal of the American Geriatrics Society · 2022Pooled it
- Characterization of the Oral Bacteria in Patients With Neuroendocrine Tumors of the Pancreas.Cancer medicine · 2026Article
- Shotgun metagenomic analysis of the tongue-coating microbiome reveals oral microbes and their functions in older adults with dementia.Journal of oral microbiology · 2026Article
- Exploring the gut-brain axis: dietary influences on Alzheimer's disease pathogenesis.Frontiers in microbiomes · 2026Review
- Supragingival Microbiota Alterations in Individuals With Sleep Bruxism: A Pilot Study.Journal of oral rehabilitation · 2025Article
- Association Between Oral Dysbiosis and Alzheimer's Disease: A Systematic Review.Journal of clinical medicine · 2025Review
- Investigation of dental health and salivary microbiota characteristics of children with visual impairment in Guangzhou, China.BMC oral health · 2025Article
- Iron Homeostasis Dysregulation, Oro-Gastrointestinal Microbial Inflammatory Factors, and Alzheimer's Disease: A Narrative Review.Microorganisms · 2025Review
- Article
- Oral Microbiome Stamp in Alzheimer's Disease.Pathogens (Basel, Switzerland) · 2024Article
- Salivary levels of disease-related biomarkers in the early stages of Parkinson's and Alzheimer's disease:IBRO neuroscience reports · 2023Article
- Article
- Subgingival microbiome at different levels of cognition.Journal of oral microbiology · 2023Article
- Advances in the prevention and treatment of Alzheimer's disease based on oral bacteria.Frontiers in psychiatry · 2023Review
- Association between adverse oral conditions and cognitive impairment: A literature review.Frontiers in public health · 2023Review
- Association between self-reported oral health and cognitive function among the community-dwelling elderly in Jinan, China: the mediating effect of life satisfaction.Frontiers in psychology · 2023Article
- Association of Alzheimer's disease and periodontitis - a systematic review and meta-analysis of evidence from observational studies.Medicine and pharmacy reports · 2022Review
- Diurnal changes of the oral microbiome in patients with alcohol dependence.Frontiers in cellular and infection microbiology · 2022Article
- The relationship between oral health status, loneliness, and sleep quality among the migrant elderly following children in Weifang, Shandong Province, China: A comparative analysis on different migration types.Frontiers in public health · 2022Article
- Molar loss further exacerbates 2-VO-induced cognitive impairment associated with the activation of p38MAPK/NFκB pathway.Frontiers in aging neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Growing evidence indicates that oral health and brain health are interconnected. Declining cognition and dementia coincide with lack of self-preservation, including oral hygiene. The oral microbiota plays an important role in maintaining oral health. Emerging evidence suggests a link between oral dysbiosis and cognitive decline in patients with Alzheimer's disease. This review showcases the recent advances connecting oral health and cognitive function during aging and the potential utility of oral-derived biospecimens to inform on brain health. Collectively, experimental findings indicate that the connection between oral health and cognition cannot be underestimated; moreover, oral biospecimens are abundant and readily obtainable without invasive procedures, which may help inform on cognitive health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.