ArticleThe Journal of physiology2019
Incubation with sodium nitrite attenuates fatigue development in intact single mouse fibres at physiological
Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Pooled it
- Effects of Dietary Nitrate Supplementation on Back Squat and Bench Press Performance: A Systematic Review and Meta-Analysis.Nutrients · 2023Pooled it
- The Effects of Dietary Nitrate Supplementation on Explosive Exercise Performance: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review.Nutrients · 2020Pooled it
- The influence of sex on the effects of inorganic nitrate supplementation on muscular power and endurance.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Trial
- The effects of inorganic nitrate supplementation on exercise economy and endurance capacity across the menstrual cycle.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Effects of Dietary Nitrate Supplementation on Performance and Muscle Oxygenation during Resistance Exercise in Men.Nutrients · 2022Trial
- Trial
- Cocoa-flavanols enhance moderate-intensity pulmonaryEuropean journal of applied physiology · 2021Trial
- Influence of exercise training on nitric oxide pathways and their physiological effects.Redox biology · 2026Review
- Effect of acute dietary nitrate intake on post-activation performance enhancement in male long jumpers.Frontiers in nutrition · 2026Article
- Acute beetroot juice supplementation augments early neuromuscular performance after blood flow restriction: a crossover study in elite basketball players.Frontiers in nutrition · 2025Article
- Effects of dietary nitrate supplementation on isometric performance and physiological responses in college bodybuilders: a randomized, double-blind, crossover study.Frontiers in nutrition · 2025Article
- Effects of Dietary Nitrate Supplementation on Performance during Single and Repeated Bouts of Short-Duration High-Intensity Exercise: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Antioxidants (Basel, Switzerland) · 2023Review
- Article
- Dietary nitrate ingested with and without pomegranate supplementation does not improve resistance exercise performance.Frontiers in nutrition · 2023Article
- Capillary-Mitochondrial Oxygen Transport in Muscle: Paradigm Shifts.Function (Oxford, England) · 2023Review
- Dietary Nitrate Supplementation Enhances Performance and Speeds Muscle Deoxyhaemoglobin Kinetics during an End-Sprint after Prolonged Moderate-Intensity Exercise.Antioxidants (Basel, Switzerland) · 2022Article
- Nitric oxide and skeletal muscle contractile function.Nitric oxide : biology and chemistry · 2022Review
- Role of parvalbumin in fatigue-induced changes in force and cytosolic calcium transients in intact single mouse myofibers.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
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Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
Abstract
key pointsDietary nitrate supplementation increases plasma nitrite concentration, which provides an oxygen-independent source of nitric oxide and can delay skeletal muscle fatigue. Nitrate supplementation has been shown to increase myofibre calcium release and force production in mouse skeletal muscle during contractions at a supra-physiological oxygen tension, but it is unclear whether nitrite exposure can delay fatigue development and improve myofibre calcium handling at a near-physiological oxygen tension. Single mouse muscle fibres acutely treated with nitrite had a lower force and cytosolic calcium concentration during single non-fatiguing contractions at a near-physiological oxygen tension. Nitrite treatment delayed fatigue development during repeated fatiguing isometric contractions at near-physiological, but not at supra-physiological, oxygen tension in combination with better maintenance of myofilament calcium sensitivity and sarcoplasmic reticulum calcium pumping. These findings improve understanding of the mechanisms by which increased skeletal muscle nitrite exposure might be ergogenic and imply that this is related to improved calcium handling. ABSTRACT: Dietary nitrate (NO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.