Evidence map›Paper›PMID 31541354›Full record

ArticleMolecular and cellular biochemistry2020

Differential effects of membrane sphingomyelin and cholesterol on agonist-induced bitter taste receptor T2R14 signaling.

Feroz Ahmed Shaik, Prashen Chelikani

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Feroz Ahmed ShaikManitoba Chemosensory Biology Research Group, Department of Oral Biology, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Prashen ChelikaniManitoba Chemosensory Biology Research Group, Department of Oral Biology, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada. Prashen.Chelikani@umanitoba.ca.ORCID http://orcid.org/0000-0003-1129-7957
Children's Hospital Research Institute of Manitoba · CA

Funding

Cystic Fibrosis Canada 491120Natural Sciences and Engineering Research Council of Canada RGPIN-2014-04099University of Manitoba Graduate Fellowship UMGF
6 · The paper itself

Abstract

Membrane lipids regulate the structure and function of G protein-coupled receptors (GPCRs). Previously we have shown that membrane cholesterol regulates the signaling of two human bitter taste receptors (T2Rs), T2R4 and T2R14. Another major plasma membrane lipid known to influence the function of membrane proteins including GPCRs is sphingomyelin. The role of sphingomyelin in T2R function is unexplored thus far. In this work, we examined the significance of sphingomyelin in T2R14 signaling. Results suggest that unavailability of membrane sphingomyelin did not affect the agonist-promoted T2R14 Ca

Indexed as

Calcium SignalingCell LineCell MembraneCholesterolHumansReceptor, Angiotensin, Type 1Receptors, G-Protein-CoupledSphingomyelinsTaste Receptors, Type 2CholesterolReceptor, Angiotensin, Type 1Receptors, G-Protein-CoupledSphingomyelinsTaste Receptors, Type 2Bitter taste receptor (T2R)CholesterolG protein-coupled receptor (GPCR)Human airway smooth muscleSphingolipidSphingomyelinase

Identifiers

PMID31541354
OpenAlexW2973421323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.