Evidence map›Paper›PMID 31541341›Full record

SynthesisJournal of neurology2019

Meta-analysis of haematoma volume, haematoma expansion and mortality in intracerebral haemorrhage associated with oral anticoagulant use.

David J Seiffge, Martina B Goeldlin, Turgut Tatlisumak, Philippe Lyrer, Urs Fischer, Stefan T Engelter, David J Werring

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  4. DOACs vs Warfarin for Post-myocardial Infarction Left Ventricular Thrombus: A GRADE-assessed Meta-Analysis With Trial Sequential Analysis of Randomized Trials.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David J SeiffgeStroke Research Centre, Institute of Neurology, University College London, Russell Square House, 10 Russell Square, London, UK. david.seiffge@insel.ch.ORCID http://orcid.org/0000-0003-3890-3849
Martina B GoeldlinDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Turgut TatlisumakDepartment of Clinical Neuroscience/Neurology, Institute of Neurosciences and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Philippe LyrerStroke Center and Neurology, Department of Clinical Research, University Hospital and University, Basel, Switzerland.
Urs FischerDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Stefan T EngelterStroke Center and Neurology, Department of Clinical Research, University Hospital and University, Basel, Switzerland.
David J WerringStroke Research Centre, Institute of Neurology, University College London, Russell Square House, 10 Russell Square, London, UK. d.werring@ucl.ac.uk.

Funding

Bayer Foundaton Thrombosis Award(DE) n/aGottfried und Julia Bangerter-Rhyner-Stiftung n/aSchweizerischen Neurologischen Gesellschaft n/ASchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung P300PB-177948
6 · The paper itself

Abstract

objectiveTo obtain precise estimates of age, haematoma volume, secondary haematoma expansion (HE) and mortality for patients with intracerebral haemorrhage (ICH) taking oral anticoagulants [Vitamin K antagonists (VKA-ICH) or non-Vitamin K antagonist oral anticoagulants (NOAC-ICH)] and those not taking oral anticoagulants (non-OAC ICH) at ICH symptom onset.

methodsWe conducted a systematic review and meta-analysis of studies comparing VKA-ICH or NOAC-ICH or both with non-OAC ICH. Primary outcomes were haematoma volume (in ml), HE, and mortality (in-hospital and 3-month). We calculated odds ratios (ORs) using the Mantel-Haenszel random-effects method and corresponding 95% confidence intervals (95%CI) and determined the mean ICH volume difference.

resultsWe identified 19 studies including data from 16,546 patients with VKA-ICH and 128,561 patients with non-OAC ICH. Only 2 studies reported data on 4943 patients with NOAC-ICH. Patients with VKA-ICH were significantly older than patients with non-OAC ICH (mean age difference: 5.55 years, 95%CI 4.03-7.07, p < 0.0001, I

conclusionThis meta-analysis confirms, refines and expands findings from prior studies. We provide precise estimates of key prognostic factors and outcomes for VKA-ICH, which has larger haematoma volume, increased rate of HE and higher mortality compared to non-OAC ICH. There are insufficient data on NOACs.

Indexed as

Cerebral HemorrhageHematomaAnticoagulantsHumansVitamin KAnticoagulantsVitamin KHaematoma expansionHaematoma volumeIntracerebral haemorrhageMortalityOral anticoagulants

Identifiers

PMID31541341
PMCPMC6851029

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.