Evidence map›Paper›PMID 31541306›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019

Reproductive outcomes following a stem cell transplant for a haematological malignancy in female cancer survivors: a systematic review and meta-analysis.

Brigitte Gerstl, Elizabeth Sullivan, Jana Koch, Handan Wand, Angela Ives, Richard Mitchell, Nada Hamad, Antoinette Anazodo

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Article
  4. Review
  5. Review
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  7. Article
  8. Article
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  10. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Brigitte GerstlDepartment of Biostatistics, The Kirby Institute, University of New South Wales, Kensington, NSW, Australia.
Elizabeth SullivanOffice of the PVC Health and Medicine, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.
Jana KochDepartment of Biostatistics, The Kirby Institute, University of New South Wales, Kensington, NSW, Australia.
Handan WandDepartment of Biostatistics, The Kirby Institute, University of New South Wales, Kensington, NSW, Australia.
Angela IvesCancer and Palliative Care Research and Evaluation Unit, University of Western Australia, Crawley, WA, Australia.
Richard MitchellKids Cancer Centre, Sydney Children's Hospital, Randwick, Sydney, NSW, 2031, Australia.
Nada HamadDepartment of Haematology, The Kinghorn Cancer Centre, St Vincent's Hospital, Darlinghurst, NSW, Australia.
Antoinette AnazodoKids Cancer Centre, Sydney Children's Hospital, Randwick, Sydney, NSW, 2031, Australia. Antoinette.anazodo@health.nsw.gov.au.ORCID http://orcid.org/0000-0002-5495-6062
UNSW Sydney · AUNew South Wales Department of Health · AUSt Vincent's Hospital Melbourne · AUThe University of Western Australia · AUUniversity of Newcastle Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe use of high-dose chemotherapy and radiotherapy combined with haematopoietic stem cell transplantation (HSCT) may negatively affect a woman's reproductive potential. Reproductive outcomes such as infertility are a major concern for women who undergo treatment for a haematological cancer diagnosis.

objectiveThis systematic review and meta-analysis explores reproductive outcomes following a haematological cancer requiring HSCT.

methodsElectronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a haematological cancer diagnosis. Studies were included that reported on pregnancy and reproductive outcomes following HSCT for a haematological malignancy.

resultsThe meta-analysis included 14 studies, collectively involving 744 female patients. The subgroup analysis showed an overall pooled estimated pregnancy rate, for autologous or allogeneic HSCT recipients, of 22.7% (n = 438). There were 25% (n = 240) of women who became pregnant after autologous HSCT compared with 22% (n = 198) who subsequently became pregnant following allogeneic HSCT.

conclusionsThis meta-analysis reflects low pregnancy rates for cancer survivors desiring a family. However, live births are improving over time with new technology and novel therapies. Hence, female cancer patients should be offered timely discussions, counselling and education around fertility preservation options prior to starting treatment with gonadotoxic therapy.

Indexed as

Pregnancy RateCancer SurvivorsFemaleFertility PreservationHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansPregnancyRandomized Controlled Trials as TopicBirthHaematological malignanciesOncofertilityPregnancyReproductive outcomeStem cell transplant

Identifiers

PMID31541306
OpenAlexW2974650832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.