Evidence map›Paper›PMID 31541215›Full record

ReviewEye (London, England)2020

The impact of artificial intelligence in the diagnosis and management of glaucoma.

Eileen L Mayro, Mengyu Wang, Tobias Elze, Louis R Pasquale

Abstract readReview
In one paragraph

Review in Eye (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Artificial intelligence in ophthalmology.International journal of ophthalmology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eileen L MayroSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. eileen.mayro@jefferson.edu.
Mengyu WangSchepens Eye Research Institute, Harvard Medical School, Boston, MA, USA.
Tobias ElzeSchepens Eye Research Institute, Harvard Medical School, Boston, MA, USA.
Louis R PasqualeDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Gene-Environment Interactions in GlaucomaR01EY015473 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI PASQUALE, LOUIS ROBERT · 2005 to 2021
$8.3M
Personalizing Glaucoma Diagnosis by Disease Specific Patterns and Individual Eye AnatomyR01EY030575 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI ELZE, TOBIAS · 2019 to 2023
$2.4M
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related StructureR00EY028631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2021 to 2023
$741k
Associating retinal nerve fiber layer thickness with glucose metabolism and diabetic retinopathyR21EY030631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI ELZE, TOBIAS · 2019 to 2020
$554k
Improved Glaucoma Monitoring Using Artificial-Intelligence Enabled DashboardR21EY031725 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI YOUSEFI, SIAMAK · 2020 to 2022
$545k
A hybrid artificial intelligence framework for glaucoma monitoringR21EY030142 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI ELZE, TOBIAS, YOUSEFI, SIAMAK · 2019 to 2020
$499k
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related StructureK99EY028631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2019 to 2020
$293k
NEI NIH HHS K99 EY028631NEI NIH HHS R00 EY028631NEI NIH HHS R01 EY015473NEI NIH HHS R01 EY030575NEI NIH HHS R21 EY030142NEI NIH HHS R21 EY030631NEI NIH HHS R21 EY031725
6 · The paper itself

Abstract

Deep learning (DL) is a subset of artificial intelligence (AI), which uses multilayer neural networks modelled after the mammalian visual cortex capable of synthesizing images in ways that will transform the field of glaucoma. Autonomous DL algorithms are capable of maximizing information embedded in digital fundus photographs and ocular coherence tomographs to outperform ophthalmologists in disease detection. Other unsupervised algorithms such as principal component analysis (axis learning) and archetypal analysis (corner learning) facilitate visual field interpretation and show great promise to detect functional glaucoma progression and differentiate it from non-glaucomatous changes when compared with conventional software packages. Forecasting tools such as the Kalman filter may revolutionize glaucoma management by accounting for a host of factors to set target intraocular pressure goals that preserve vision. Activation maps generated from DL algorithms that process glaucoma data have the potential to efficiently direct our attention to critical data elements embedded in high throughput data and enhance our understanding of the glaucomatous process. It is hoped that AI will realize more accurate assessment of the copious data encountered in glaucoma management, improving our understanding of the disease, preserving vision, and serving to enhance the deep bonds that patients develop with their treating physicians.

Indexed as

Artificial IntelligenceGlaucomaAlgorithmsAnimalsHumansIntraocular PressureVisual Fields

Identifiers

PMID31541215
PMCPMC7002653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.