Evidence map›Paper›PMID 31541214›Full record

ReviewNature reviews. Neurology2019

Diagnosis and management of Guillain-Barré syndrome in ten steps.

Sonja E Leonhard, Melissa R Mandarakas, Francisco A A Gondim, Kathleen Bateman, Maria L B Ferreira, David R Cornblath, Pieter A van Doorn, Mario E Dourado, Richard A C Hughes, Badrul Islam and 11 more

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 465 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
465citing papers in PubMed, 6 pooled it
54.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05461898 narecruitingnot on this mapstarted 2023, after this paper: background citation

RehabGBs: Rehabilitation in People With Guillain-Barré Syndrome

TypeinterventionalSponsorCentro de Reabilitacao do NorteRan2023 to 2026Enrolled74ConditionsGuillain-Barré SyndromeArmsInpatient Rehabilitation, Inspiratory muscle training
NCT06300359 unknown statusnot on this mapstarted 2024, after this paper: background citation

Prognostic Indicators of Gullian-Barre Syndrome at Assiut University Children Hospital

TypeobservationalSponsorAssiut UniversityRan2024 to 2025Enrolled60ConditionsGuillain-Barre Syndrome
3 · Its place in the literature

Who cites it

465 citing papers in PubMed, 6 syntheses or guidelines pooled it, 826 citations in OpenAlex.

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  12. Therapeutic plasma exchange without anticoagulation: Single-center experience.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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405 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 17 institutions in 12 countries.

Sonja E LeonhardDepartment of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands.ORCID http://orcid.org/0000-0003-4832-6926
Melissa R MandarakasDepartment of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands.
Francisco A A GondimHospital Universitário Walter Cantidio, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.ORCID http://orcid.org/0000-0002-8957-5796
Kathleen BatemanGroote Schuur Hospital, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-0213-7102
Maria L B FerreiraDepartment of Neurology, Hospital da Restauração, Recife, Pernambuco, Brazil.
David R CornblathDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pieter A van DoornDepartment of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands.
Mario E DouradoDepartment of Integrative Medicine, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Richard A C HughesUCL Queen Square Institute of Neurology, University College London, London, UK.
Badrul IslamInternational Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Susumu KusunokiKindai University Faculty of Medicine, Osaka, Japan.
Carlos A PardoDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ricardo ReisinHospital Británico, Buenos Aires, Argentina.
James J SejvarCenters for Disease Control and Prevention, Atlanta, GA, USA.
Nortina ShahrizailaDepartment of Neurology, University of Malaya, Kuala Lumpur, Malaysia.
Cristiane SoaresHospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil.
Thirugnanam UmapathiNational Neuroscience Institute, Singapore, Singapore.
Yuzhong WangDepartment of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Eppie M YiuDepartment of Neurology, The Royal Children's Hospital Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-6704-8402
Hugh J WillisonCollege of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Bart C JacobsDepartment of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands. b.jacobs@erasmusmc.nl.ORCID http://orcid.org/0000-0002-8985-2458
Erasmus MC · NLJohns Hopkins University · USAffiliated Hospital of Jining Medical University · CNCenters for Disease Control and Prevention · USHospital Británico de Buenos Aires · ARHospital da Restauração · BRHospital Federal dos Servidores do Estado · BRInternational Centre for Diarrhoeal Disease Research · BDKindai University · JPNational Hospital for Neurology and Neurosurgery · GBNational Neuroscience Institute · SGRoyal Children's Hospital · AUUniversidade Federal do Ceará · BRUniversidade Federal do Rio Grande do Norte · BRUniversity of Cape Town · ZAUniversity of Glasgow · GBUniversity of Malaya · MY

Funding

Wellcome Trust
6 · The paper itself

Abstract

Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and 2015 in Latin America. Diagnosis and management of GBS can be complicated as its clinical presentation and disease course are heterogeneous, and no international clinical guidelines are currently available. To support clinicians, especially in the context of an outbreak, we have developed a globally applicable guideline for the diagnosis and management of GBS. The guideline is based on current literature and expert consensus, and has a ten-step structure to facilitate its use in clinical practice. We first provide an introduction to the diagnostic criteria, clinical variants and differential diagnoses of GBS. The ten steps then cover early recognition and diagnosis of GBS, admission to the intensive care unit, treatment indication and selection, monitoring and treatment of disease progression, prediction of clinical course and outcome, and management of complications and sequelae.

Indexed as

Disease ManagementGenetic VariationGuillain-Barre SyndromeHumansZika Virus Infection

Identifiers

PMID31541214
PMCPMC6821638
OpenAlexW2973791718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.