Evidence map›Paper›PMID 31541023›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Identification of a Novel Role for Foxo3 Isoform2 in Osteoclastic Inhibition.

Cheng Xu, Gregory J Vitone, Kazuki Inoue, Courtney Ng, Baohong Zhao

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cheng XuArthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021.
Gregory J VitoneArthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021.ORCID 0000-0001-9104-265X
Kazuki InoueArthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021.
Courtney NgArthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021.
Baohong ZhaoArthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021; zhaob@hss.edu.ORCID 0000-0002-1286-0919
Hospital for Special Surgery · US

Funding

Regulation of Osteoclastogenesis and Arthritic Bone Resorption by RBP-JR01AR071463 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI Baohong Zhao · 2017 to 2026
$4.0M
Mechanisms of inflammatory bone remodelingR01AR068970 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ZHAO, BAOHONG · 2016 to 2021
$1.9M
Regulation of Osteoclastogenesis and Arthritic Bone Resorption by RBP-JR00AR062047 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ZHAO, BAOHONG · 2014 to 2016
$747k
Regulation of Osteoclastogenesis and Arthritic Bone Resorption by RBP-JK99AR062047 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ZHAO, BAOHONG · 2012 to 2013
$187k
NIAMS NIH HHS K99 AR062047NIAMS NIH HHS R00 AR062047NIAMS NIH HHS R01 AR068970NIAMS NIH HHS R01 AR071463
6 · The paper itself

Abstract

Foxo3 acts as an important central regulator that integrates signaling pathways and coordinates cellular responses to environmental changes. Recent studies show the involvement of Foxo3 in osteoclastogenesis and rheumatoid arthritis, which prompted us to further investigate the

Indexed as

AnimalsCell DifferentiationCells, CulturedForkhead Box Protein O3HEK293 CellsHumansInterferon Type IMiceMice, Inbred C57BLOsteoclastsOsteogenesisPhenotypeProtein IsoformsRAW 264.7 CellsForkhead Box Protein O3FOXO3 protein, humanFoxO3 protein, mouseInterferon Type IProtein Isoforms

Identifiers

PMID31541023
PMCPMC6783374
OpenAlexW2973289882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.