Evidence map›Paper›PMID 31541002›Full record

ArticleeNeuro

Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D

Maria-Daniela Cirnaru, Chiara Melis, Tomas Fanutza, Swati Naphade, Kizito-Tshitoko Tshilenge, Brian S Muntean, Kirill A Martemyanov, Joshua L Plotkin, Lisa M Ellerby, Michelle E Ehrlich

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
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  4. Bmal1 Modulates Striatal cAMP Signaling and Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  12. Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Maria-Daniela CirnaruDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Chiara MelisDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0002-8752-7520
Tomas FanutzaDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Swati NaphadeThe Buck Institute for Research on Aging, Novato, California 94945.
Kizito-Tshitoko TshilengeThe Buck Institute for Research on Aging, Novato, California 94945.
Brian S MunteanDepartment of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458.
Kirill A MartemyanovDepartment of Neuroscience, The Scripps Research Institute, Jupiter, Florida 33458.ORCID 0000-0002-9925-7599
Joshua L PlotkinDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794.
Lisa M EllerbyThe Buck Institute for Research on Aging, Novato, California 94945.
Michelle E EhrlichDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York 10029 Michelle.ehrlich@mssm.edu.
Buck Institute for Research on Aging · USIcahn School of Medicine at Mount Sinai · USScripps Research Institute · USMount Sinai Hospital · USStony Brook University · US

Funding

Identifying Factors Regulating Medium Spiny Neuron Differentiation or Maintenance as Therapeutic Targets for Huntington's Disease using Induced Pluripotent Stem CellsR01NS100529 · NINDS · BUCK INSTITUTE FOR RESEARCH ON AGING · PI Lisa M Ellerby · 2016 to 2026
$5.6M
Molecular Basis of RGS Protein Function in the StriatumK02DA026405 · NIDA · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A. · 2009 to 2019
$1.2M
NIDA NIH HHS K02 DA026405NINDS NIH HHS R01 NS100529
6 · The paper itself

Abstract

The GABAergic medium-size spiny neuron (MSN), the striatal output neuron, may be classified into striosome, also known as patch, and matrix, based on neurochemical differences between the two compartments. At this time, little is known regarding the regulation of the development of the two compartments.

Indexed as

AnimalsAnimals, NewbornCells, CulturedCocaineCorpus StriatumDopamine Uptake InhibitorsHumansLocomotionMaleMiceMice, KnockoutMice, TransgenicNeuronsNuclear Receptor Subfamily 4, Group A, Member 1Receptors, Dopamine D1Signal TransductionCocaineDopamine Uptake InhibitorsDrd1 protein, mouseNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Receptors, Dopamine D1dopamine receptor D1ERKNr4a1signalstriosometransduction

Identifiers

PMID31541002
PMCPMC6787343
OpenAlexW2974384901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.