Evidence map›Paper›PMID 31540914›Full record

ArticleDevelopment (Cambridge, England)2019

Requirement for scleraxis in the recruitment of mesenchymal progenitors during embryonic tendon elongation.

Alice H Huang, Spencer S Watson, Lingyan Wang, Brendon M Baker, Haruhiko Akiyama, John V Brigande, Ronen Schweitzer

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Achieving tendon enthesis regeneration across length scales.Current opinion in biomedical engineering · 2024
    Article
  4. Interfacial Tissue Regeneration with Bone.Current osteoporosis reports · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Phenotype stability, expansion potential, and senescence of embryonic tendon cells in vitro.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  9. Growth and mechanobiology of the tendon-bone enthesis.Seminars in cell & developmental biology · 2022
    Review
  10. Article
  11. Comparison of Tendon Development Versus Tendon Healing and Regeneration.Frontiers in cell and developmental biology · 2022
    Review
  12. Article
  13. Article
  14. Effects of tamoxifen on tendon homeostasis and healing: Considerations for the use of tamoxifen-inducible mouse models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Article
  15. Article
  16. Article
  17. Development and maintenance of tendons and ligaments.Development (Cambridge, England) · 2021
    Review
  18. Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Review
  19. 4D formation of human embryonic forelimb musculature.Development (Cambridge, England) · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Alice H HuangResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA alice.huang@mssm.edu schweitz@ohsu.edu.ORCID 0000-0002-5037-6829
Spencer S WatsonResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA.
Lingyan WangOregon Hearing Research Center, Oregon Health & Science University, Portland, OR 97239, USA.
Brendon M BakerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Haruhiko AkiyamaDepartment of Orthopaedics, Gifu University, Gifu City 501-1194, Japan.
John V BrigandeOregon Hearing Research Center, Oregon Health & Science University, Portland, OR 97239, USA.
Ronen SchweitzerResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA alice.huang@mssm.edu schweitz@ohsu.edu.
Shriners Hospitals for Children - Portland · USOregon Health & Science University · USGifu University Hospital · JPUniversity of Michigan · US

Funding

Molecular Embryology of the Mammalian Inner EarR01DC008595 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI BRIGANDE, JOHN VINCENT · 2007 to 2018
$4.0M
Transcriptional regulation of tendon differentiation and matrix formationR01AR055973 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHWEITZER, RONEN · 2010 to 2014
$1.7M
REGULATION OF TENDON INDUCTION AND FORMATION BY TGFbeta SIGNALINGR01AR055640 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHWEITZER, RONEN · 2007 to 2011
$1.6M
NIAMS NIH HHS R01 AR055640NIAMS NIH HHS R01 AR055973NIDCD NIH HHS R01 DC008595
6 · The paper itself

Abstract

The transcription factor scleraxis (

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCell DifferentiationCell MovementMiceSOX9 Transcription FactorStem CellsTendonsBasic Helix-Loop-Helix ProteinsScx protein, mouseSox9 protein, mouseSOX9 Transcription FactorMouseMusculoskeletalScleraxisTendon development

Identifiers

PMID31540914
PMCPMC6826031
OpenAlexW2974160378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.