Evidence map›Paper›PMID 31540910›Full record

ReviewDevelopment (Cambridge, England)2019

The control of gene expression and cell identity by H3K9 trimethylation.

Maria Ninova, Katalin Fejes Tóth, Alexei A Aravin

Open access · bronzeAbstract readReview
In one paragraph

Review in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 159 citations in OpenAlex.

  1. Article
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  13. Stochastic modeling of epigenetic memory.NPJ systems biology and applications · 2026
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Epigenetics and chromatin structure regulatebioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maria NinovaCalifornia Institute of Technology, Division of Biology and Biological Engineering, 147-75, 1200 East California Boulevard, Pasadena, CA 91125, USA.ORCID 0000-0001-5051-5502
Katalin Fejes TóthCalifornia Institute of Technology, Division of Biology and Biological Engineering, 147-75, 1200 East California Boulevard, Pasadena, CA 91125, USA aaa@caltech.edu kft@caltech.edu.ORCID 0000-0001-6558-2636
Alexei A AravinCalifornia Institute of Technology, Division of Biology and Biological Engineering, 147-75, 1200 East California Boulevard, Pasadena, CA 91125, USA aaa@caltech.edu kft@caltech.edu.
California Institute of Technology · US

Funding

Molecular Mechanism of the piRNA BiogenesisR01GM097363 · NIGMS · CORNELL UNIVERSITY · PI ARAVIN, ALEXEI A. · 2011 to 2025
$4.0M
Understanding the mechanism of Piwi-induced transcriptional silencingR01GM110217 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FEJES TOTH, KATALIN · 2014 to 2024
$3.1M
Elucidating the role of SUMO ligase Su(var)2-10 in piRNA-guided transcriptional silencing and repressive chromatin formationK99HD099316 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI NINOVA, MARIA ANTONINOVA · 2019 to 2020
$259k
NICHD NIH HHS K99 HD099316NIGMS NIH HHS R01 GM097363NIGMS NIH HHS R01 GM110217
6 · The paper itself

Abstract

Histone 3 lysine 9 trimethylation (H3K9me3) is a conserved histone modification that is best known for its role in constitutive heterochromatin formation and the repression of repetitive DNA elements. More recently, it has become evident that H3K9me3 is also deposited at certain loci in a tissue-specific manner and plays important roles in regulating cell identity. Notably, H3K9me3 can repress genes encoding silencing factors, pointing to a fundamental principle of repressive chromatin auto-regulation. Interestingly, recent studies have shown that H3K9me3 deposition requires protein SUMOylation in different contexts, suggesting that the SUMO pathway functions as an important module in gene silencing and heterochromatin formation. In this Review, we discuss the role of H3K9me3 in gene regulation in various systems and the molecular mechanisms that guide the silencing machinery to target loci.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsFeedback, PhysiologicalHeterochromatinHistonesHumansLysineMethylationHeterochromatinHistonesLysineCell fate maintenanceChromatinEpigeneticsGene regulationGermlineHeterochromatinTranscriptional repressionTransposons

Identifiers

PMID31540910
PMCPMC6803365
OpenAlexW2974907528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.