Evidence map›Paper›PMID 31540902›Full record

ArticleBlood advances2019

MMP9 inhibition increases erythropoiesis in RPS14-deficient del(5q) MDS models through suppression of TGF-β pathways.

Minyoung Youn, Haigen Huang, Cheng Chen, Sharon Kam, Mark C Wilkes, Hee-Don Chae, Kunju J Sridhar, Peter L Greenberg, Bertil Glader, Anupama Narla and 2 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

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  14. Using the Zebrafish as a Genetic Model to Study Erythropoiesis.International journal of molecular sciences · 2021
    Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Minyoung YounDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Haigen HuangDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA; and.
Cheng ChenDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA; and.
Sharon KamDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Mark C WilkesDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Hee-Don ChaeDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Kunju J SridharStanford University Cancer Center, Stanford, CA.
Peter L GreenbergStanford University Cancer Center, Stanford, CA.
Bertil GladerDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Anupama NarlaDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Shuo LinDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA; and.
Kathleen M SakamotoDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA.
Stanford University · USUniversity of California, Los Angeles · US

Funding

Training in Pediatric Nonmalignant Hematology and Stem Cell BiologyT32DK098132 · NIDDK · STANFORD UNIVERSITY · PI SAKAMOTO, KATHLEEN M · 2014 to 2022
$1.9M
Signaling Pathways in MDSR01DK107286 · NIDDK · STANFORD UNIVERSITY · PI SAKAMOTO, KATHLEEN M · 2016 to 2019
$1.4M
NIDDK NIH HHS R01 DK107286NIDDK NIH HHS T32 DK098132
6 · The paper itself

Abstract

The del(5q) myelodysplastic syndrome (MDS) is a distinct subtype of MDS, associated with deletion of the ribosomal protein S14 (

Indexed as

ErythropoiesisHumansMatrix Metalloproteinase 9Transforming Growth Factor betaMatrix Metalloproteinase 9Transforming Growth Factor beta

Identifiers

PMID31540902
PMCPMC6759738
OpenAlexW2973536301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.