Evidence map›Paper›PMID 31540485›Full record

ArticleCancers2019

TWIST1 Heterodimerization with E12 Requires Coordinated Protein Phosphorylation to Regulate Periostin Expression.

Svetlana A Mikheeva, Nathan D Camp, Lei Huang, Antrix Jain, Sung Yun Jung, Naze G Avci, Mari Tokita, Alejandro Wolf-Yadlin, Jing Zhang, Stephen J Tapscott and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cranium growth, patterning and homeostasis.Development (Cambridge, England) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Svetlana A MikheevaDepartment of Neurosurgery, Houston Methodist Research Institute, Houston, TX 77030, USA. smikheeva@houstonmethodist.org.
Nathan D CampInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. nathandcamp@gmail.com.
Lei HuangDepartment of Systems Medicine & Bioengineering, Houston Methodist Research Institute, Houston, TX 77030, USA. lhuang@houstonmethodist.org.
Antrix JainBaylor College of Medicine, Houston, TX 77030, USA. antrixj@bcm.edu.ORCID 0000-0002-2815-3645
Sung Yun JungBaylor College of Medicine, Houston, TX 77030, USA. syjung@bcm.edu.ORCID 0000-0003-1521-7977
Naze G AvciDepartment of Neurosurgery, Houston Methodist Research Institute, Houston, TX 77030, USA. nazeavci@gmail.com.
Mari TokitaDivision of Medical Genetics, University of Washington, Seattle, WA 98195, USA. mari.tokita@gmail.com.
Alejandro Wolf-YadlinSeattle Genetics, Bothell, WA 98021, USA. awolf-yadlin@seagen.com.
Jing ZhangDivision of Neuropathology, Department of Pathology, University of Washington, Seattle, WA 98195, USA. zhangj@uw.edu.
Stephen J TapscottFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. stapscot@fredhutch.org.
Robert C RostomilyDepartment of Neurosurgery, Houston Methodist Research Institute, Houston, TX 77030, USA. rrostomily@houstonmethodist.org.ORCID 0000-0003-1431-162X
Andrei M MikheevDepartment of Neurosurgery, Houston Methodist Research Institute, Houston, TX 77030, USA. amikheev@houstonmethodist.org.
Houston Methodist · USBaylor College of Medicine · USUniversity of Washington · USFred Hutch Cancer Center · USSeagen (United States) · USUniversity of Washington Medical Center · US

Funding

Tumor mutation signaturesP01CA077852 · NCI · UNIVERSITY OF WASHINGTON · PI MONNAT, RAYMOND J · 1999 to 2019
$26.0M
Therapeutically relevant targets of Twist1 dimers in gliomaR01NS091251 · NINDS · UNIVERSITY OF WASHINGTON · PI ROSTOMILY, ROBERT C · 2015 to 2020
$1.8M
TWIST1 as a target for inhibition of glioma invasionR01CA136808 · NCI · UNIVERSITY OF WASHINGTON · PI ROSTOMILY, ROBERT C · 2011 to 2015
$1.7M
Generation of TWIST1 reporters through characterization of TWIST1 dependent netwoR21NS082542 · NINDS · UNIVERSITY OF WASHINGTON · PI MIKHEEV, ANDREI M · 2013 to 2014
$476k
NCI NIH HHS P01 CA077852NCI NIH HHS P01CA077852NCI NIH HHS R01CA136808NINDS NIH HHS R01 NS091251NINDS NIH HHS R01NS091251NINDS NIH HHS R21 NS082542NINDS NIH HHS R21NS082542
6 · The paper itself

Abstract

Diffuse invasion into adjacent brain matter by glioblastoma (GBM) is largely responsible for their dismal prognosis. Previously, we showed that the TWIST1 (TW) bHLH transcription factor and its regulated gene periostin (

Indexed as

dimerizationglioblastomainvasionperiostinTWIST1

Identifiers

PMID31540485
PMCPMC6770789
OpenAlexW2993589564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.