Evidence map›Paper›PMID 31540446›Full record

ArticleJournal of clinical medicine2019

Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers.

Barbara De Angelis, Margarida Fernandes Lopes Morais D'Autilio, Fabrizio Orlandi, Giampiero Pepe, Simone Garcovich, Maria Giovanna Scioli, Augusto Orlandi, Valerio Cervelli, Pietro Gentile

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 7 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 7 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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  5. The use of platelet-rich plasma in wound healing and vitiligo: A systematic review and meta-analysis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Pooled it
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  8. Translational development of ABCB5Stem cell research & therapy · 2022
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Barbara De AngelisDepartment of Surgical Science, University of Rome Tor Vergata, Rome 00133, Italy. bdeangelisdoc@gmail.com.
Margarida Fernandes Lopes Morais D'AutilioDepartment of Surgical Science, University of Rome Tor Vergata, Rome 00133, Italy. mflmdautilio@gmail.com.
Fabrizio OrlandiDepartment of Surgical Science, University of Rome Tor Vergata, Rome 00133, Italy. fabrizio.orlandi86@gmail.com.ORCID 0000-0001-8241-1812
Giampiero PepeDepartment of Surgical Science, University of Rome Tor Vergata, Rome 00133, Italy. giampieropepe.rm@gmail.com.
Simone GarcovichInstitute of Dermatology, F. Policlinico Gemelli IRCSS, Università Cattolica del Sacro Cuore, Rome 00168, Italy. simgarko@yahoo.it.
Maria Giovanna ScioliDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, Rome 00133, Italy. scioli@med.uniroma2.it.
Augusto OrlandiDepartment of Biomedicine and Prevention, Tor Vergata University of Rome, Rome 00133, Italy. orlandi@uniroma2.it.ORCID 0000-0001-7202-5854
Valerio CervelliDepartment of Surgical Science, University of Rome Tor Vergata, Rome 00133, Italy. valeriocervelli@virgilio.it.
Pietro GentileDepartment of Surgical Science, University of Rome Tor Vergata, Rome 00133, Italy. pietrogentile2004@libero.it.ORCID 0000-0003-3123-3977
University of Rome Tor Vergata · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic ulcers are characterized by loss of substance without a normal tendency towards spontaneous healing. The Wound Bed Preparation Guideline advises that after diagnosis, the expert should correct the biological state of the ulcer micro-environment based on TIME principles (Tissue, Infection, Moisture balance, Epidermal). There are many ways to treat such ulcers, for example through use of advanced dressings, negative pressure, surgical toilets, dermal substitutes, autologous skin grafting, and free or local flaps. In vitro and in vivo pre-clinical models hold widely acknowledged potential yet complex limitations. Tissue bioengineering could be an ideal approach to foster innovative strategies in wound healing. Our observational study reports on an in vitro and in vivo evaluation of a bio-functionalized scaffold composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) used in 182 patients affected by chronic ulcers (diabetic and vascular), comparing the results with a control group of 182 patients treated with traditional dressings (HA alone). After 30 days the patients who had undergone the combined treatment (PRP + HA), showed 96.8% ± 1.5% re-epithelialization, as compared to 78.4% ± 4.4% in the control group (HA only). Within 80 days, they had 98.4% ± 1.3% re-epithelialization as compared to 87.8% ± 4.1% in the control group (HA only;

Indexed as

hyaluronic acidplatelet-rich plasmaregenerative plastic surgerywound healing

Identifiers

PMID31540446
PMCPMC6780765
OpenAlexW2973605206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.