Evidence map›Paper›PMID 31540384›Full record

Trial reportNutrients2019

Generation of the Antioxidant Hydroxytyrosol from Tyrosol Present in Beer and Red Wine in a Randomized Clinical Trial.

Natalia Soldevila-Domenech, Anna Boronat, Julian Mateus, Patricia Diaz-Pellicer, Iris Matilla, Marta Pérez-Otero, Ana Aldea-Perona, Rafael de la Torre

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
  8. Wine, Polyphenols, and the Matrix Effect: Is Alcohol Always the Same?International journal of molecular sciences · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Polyphenols: From Theory to Practice.Foods (Basel, Switzerland) · 2021
    Review
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Natalia Soldevila-DomenechIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain. natalia.soldevila01@gmail.com.
Anna BoronatIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Department of Experimental and Health Sciences, University Pompeu Fabra, 08003 Barcelona, Spain. aboronat@imim.es.
Julian MateusIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), School of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. jmateus@imim.es.
Patricia Diaz-PellicerIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), School of Medicine, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. 62234@parcdesalutmar.cat.
Iris MatillaIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain. imatilla@imim.es.
Marta Pérez-OteroIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain. mperez2@imim.es.
Ana Aldea-PeronaIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain. aaldea@imim.es.
Rafael de la TorreIntegrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Department of Experimental and Health Sciences, University Pompeu Fabra, CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain. rtorre@imim.es.ORCID 0000-0002-6765-1866
Hospital Del Mar · ESUniversitat Autònoma de Barcelona · ESUniversitat Pompeu Fabra · ESInstituto de Salud Carlos III · ES

Funding

Centro de Información Cerveza y Salud Manuel de Oya Research FellowshipDepartament d'Innovació, Universitats i Empresa, Generalitat de Catalunya SGR138Instituto de Salud Carlos III CM17/00024Instituto de Salud Carlos III PFIS-FI16/00106
6 · The paper itself

Abstract

Beer and wine contains the simple phenol tyrosol (TYR) which is endogenously converted into hydroxytyrosol (HT), one of the strongest dietary antioxidants, by

Indexed as

BeerWineAdultAntioxidantsBiotransformationCross-Over StudiesCytochrome P-450 CYP2A6Cytochrome P-450 CYP2D6FemaleGenotypeHumansMalePhenylethyl AlcoholYoung Adult3,4-dihydroxyphenylethanol4-hydroxyphenylethanolAntioxidantsCYP2A6 protein, humanCytochrome P-450 CYP2A6Cytochrome P-450 CYP2D6Phenylethyl AlcoholalcoholbeerCYP2A6CYP2D6hydroxytyrosolmetabolismpolygenic activity scoretyrosolwine

Identifiers

PMID31540384
PMCPMC6769679
OpenAlexW2974209462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.