Evidence map›Paper›PMID 31540257›Full record

ArticleInternational journal of molecular sciences2019

Comparative Transcriptomic and Lipidomic Analyses of Human Male and Female Meibomian Glands Reveal Common Signature Genes of Meibogenesis.

Igor A Butovich, Nita Bhat, Jadwiga C Wojtowicz

Open access · goldAbstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Effects of Aging on Human Meibum.Investigative ophthalmology & visual science · 2021
    Article
  9. Article
  10. Article
  11. Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Meibomian gland development: Where, when and how?Differentiation; research in biological diversity
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Igor A ButovichDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. igor.butovich@utsouthwestern.edu.
Nita BhatDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. nbhat@houstonmethodist.org.
Jadwiga C WojtowiczDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. fenotipojw@gmail.com.
The University of Texas Southwestern Medical Center · US

Funding

Meibogenesis in Health, Disease, and Aging - Administrative SupplementR01EY027349 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI BUTOVICH, IGOR A · 2017 to 2025
$2.9M
Biochemistry and Biophysics of the Preocular Tear FilmR01EY019480 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI BUTOVICH, IGOR A · 2010 to 2014
$1.7M
NEI NIH HHS R01 EY019480NEI NIH HHS R01 EY027349Research to Prevent Blindness Unrestricted grant
6 · The paper itself

Abstract

Meibum is a lipid secretion that is produced by holocrine Meibomian glands (MGs). MGs are a specialized type of sebaceous glands that are embedded in the human eyelids. Chemically, meibum and sebum are different. A detailed characterization of lipidome and transcriptome of MG is required to deconvolute a complex and poorly characterized array of biosynthetic reactions (termed

Indexed as

AdultAgedAged, 80 and overFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansLipidomicsMaleMeibomian GlandsMiddle AgedOligonucleotide Array Sequence Analysischromatographygeneslipidsmass spectrometrymeibogenesismeibomian glandsmeibum

Identifiers

PMID31540257
PMCPMC6769918
OpenAlexW2972449577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.