Evidence map›Paper›PMID 31540208›Full record

ArticleNutrients2019

Food-Intake Normalization of Dysregulated Fatty Acids in Women with Anorexia Nervosa.

Nhien Nguyen, Michelle Dow, Blake Woodside, J Bruce German, Oswald Quehenberger, Pei-An Betty Shih

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03100656 (Solving EPHX2 and Polyunsaturated Fatty Acid Interactions in Anorexia Nervosa), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03100656 narecruitingnot on this map

Solving EPHX2 and Polyunsaturated Fatty Acid Interactions in Anorexia Nervosa

TypeinterventionalSponsorUniversity of California, San DiegoRan2016 to 2027Enrolled300ConditionsAnorexia NervosaArmsA breakfast sandwich
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Nhien NguyenDepartment of Psychiatry, School of Medicine University of California, San Diego, La Jolla, CA 92037, USA. n7nguyen@ucsd.edu.
Michelle DowDivision of Medical Genetics, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. mdow@eng.ucsd.edu.
Blake WoodsideDepartment of Psychiatry, University of Toronto, Toronto, ON M5T 2S8, Canada. b.woodside@utoronto.ca.
J Bruce GermanDepartment of Food Science & Technology, University of California, Davis, Davis, CA 95616, USA. jbgerman@ucdavis.edu.
Oswald QuehenbergerDepartment of Pharmacology, University of California, San Diego, San Diego, CA 92093, USA. oquehenberger@ucsd.edu.ORCID 0000-0001-8950-9169
Pei-An Betty ShihDepartment of Psychiatry, School of Medicine University of California, San Diego, La Jolla, CA 92037, USA. pbshih@ucsd.edu.
University of California San Diego · USUniversity of California, Davis · USUniversity of California San Diego Medical Center · USUniversity of Toronto · CA

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Solving EPHX2 and PUFA Interactions in Anorexia NervosaR01MH106781 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHIH, PEI-AN (BETTY) · 2016 to 2020
$2.0M
NIH HHS UL1TR001442NIMH NIH HHS R01 MH106781NIMH NIH HHS R01MH106781
6 · The paper itself

Abstract

Anorexia nervosa (AN) is a psychiatric disorder affected by psychological, environmental, and biological factors. Individuals with AN avoid high-fat, high-calorie diets and have shown abnormal metabolism of fatty acids (FAs), which are essential for brain and cognitive/neuropsychiatric health. To clarify the relationship between FAs and AN, fasting and postprandial plasma FAs in AN patients and age-matched control women were analyzed via mass-spectrometry. Clinical phenotypes were assessed using Becker Anxiety Inventory and Becker Depression Inventory. AN patients and controls exhibited different FA signatures at both fasting and postprandial timepoints. Lauric acid, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and alpha-linoleic acid (ALA) were higher in AN than in controls (lauric acid: 15,081.6 ± 14,970.2 vs. 8257.4 ± 4740.2 pmol/mL; ALA at fasting: 2217.7 ± 1587.6 vs. 1087.9 ± 821.2 pmol/mL; ALA at postprandial: 1830.9 ± 1115.6 vs. 1159.4 ± 664.7 pmol/mL. EPA: 33,788.3 ± 17,487.5 vs. 22,860.6 ± 12,642.4 pmol/mL; DPA: 32,664.8 ± 16,215.0 vs. 20,969.0 ± 12,350.0 pmol/mL. FDR-adjusted

Indexed as

AdultAnorexia NervosaAnxietyDepressionEatingEicosapentaenoic AcidFastingFatty Acid DesaturasesFatty Acid ElongasesFatty AcidsFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, UnsaturatedFemaleHumansPostprandial Perioddocosapentaenoic acidEicosapentaenoic AcidFatty Acid DesaturasesFatty Acid ElongasesFatty AcidsFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, Unsaturatedanorexia nervosafatty acidsmetabolic dysregulation

Identifiers

PMID31540208
PMCPMC6769727
OpenAlexW2973219242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.