Evidence map›Paper›PMID 31540200›Full record

ReviewMicroorganisms2019

Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface.

Matthew R Pennington, Amrita Saha, David F Painter, Christina Gavazzi, Ashrafali M Ismail, Xiaohong Zhou, James Chodosh, Jaya Rajaiya

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microorganisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Mucosal immune responses toMarine life science & technology · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Matthew R PenningtonHowe Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. matthew_pennington@meei.harvard.edu.
Amrita SahaHowe Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. amrita_saha@meei.harvard.edu.
David F PainterHowe Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. david_painter@meei.harvard.edu.ORCID 0000-0003-4987-0448
Christina GavazziHowe Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. christina_gavazzi@college.harvard.edu.
Ashrafali M IsmailHowe Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. mohamed_ismail@meei.harvard.edu.ORCID 0000-0001-8694-7235
Xiaohong ZhouHowe Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. xiaohong_zhou@meei.harvard.edu.
James ChodoshHowe Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. james_chodosh@meei.harvard.edu.ORCID 0000-0002-7463-1599
Jaya RajaiyaHowe Laboratory, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA. jaya_rajaiya@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · US

Funding

Immunopathogenesis of Adenovirus KeratitisR01EY013124 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI James Chodosh, Jaya Rajaiya · 2001 to 2026
$10.8M
Novel Mechanisms in Adenoviral Ocular PathogenesisR01EY021558 · NEI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI James Chodosh, Jaya Rajaiya · 2011 to 2026
$7.1M
Falk Foundation 2400100Massachusetts Lions Eye Research Fund 530739NEI NIH HHS EY013124, EY021558, EY014104, and 5T32EY007145-20NEI NIH HHS R01 EY013124NEI NIH HHS R01 EY021558Research to Prevent Blindness 530062
6 · The paper itself

Abstract

Human adenovirus infection of the ocular surface is associated with severe keratoconjunctivitis and the formation of subepithelial corneal infiltrates, which may persist and impair vision for months to years following infection. Long term pathology persists well beyond the resolution of viral replication, indicating that the prolonged immune response is not virus-mediated. However, it is not clear how these responses are sustained or even initiated following infection. This review discusses recent work from our laboratory and others which demonstrates different entry pathways specific to both adenovirus and cell type. These findings suggest that adenoviruses may stimulate specific pattern recognition receptors in an entry/trafficking-dependent manner, leading to distinct immune responses dependent on the virus/cell type combination. Additional work is needed to understand the specific connections between adenoviral entry and the stimulation of innate immune responses by the various cell types present on the ocular surface.

Indexed as

adenoviruscaveolinclathrincorneadynaminendocytosisentryepidemic keratoconjunctivitisinnate immunitymacropinocytosisocular surfacereceptorstrafficking

Identifiers

PMID31540200
PMCPMC6780103
OpenAlexW2972424269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.