ArticleVaccines2019
Tick Bites Induce Anti-α-Gal Antibodies in Dogs.
Article in Vaccines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Alpha-Gal syndrome unveiled: decoding the glycan-driven red meat allergy.Glycoconjugate journal · 2026Review
- From vector to allergen: exploring the immunology of tick-triggered α-Gal syndrome.Frontiers in immunology · 2026Review
- Constructing the first comorbidity networks in companion dogs in the Dog Aging Project.PLoS computational biology · 2025Article
- Constructing the first comorbidity networks in companion dogs in the Dog Aging Project.bioRxiv : the preprint server for biology · 2025Article
- High levels of alpha-gal with large variation in the salivary glands of lone star ticks fed on human blood.Scientific reports · 2023Article
- Where's the Beef? Understanding Allergic Responses to Red Meat in Alpha-Gal Syndrome.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Exploring the Ecological Implications of Microbiota Diversity in Birds: Natural Barriers Against Avian Malaria.Frontiers in immunology · 2022Article
- Tick Saliva and the Alpha-Gal Syndrome: Finding a Needle in a Haystack.Frontiers in cellular and infection microbiology · 2021Review
- The α-Gal Syndrome and Potential Mechanisms.Frontiers in allergy · 2021Review
- Importation of Ticks on Companion Animals and the Risk of Spread of Tick-Borne Diseases to Non-Endemic Regions in Europe.Animals : an open access journal from MDPI · 2020Article
- Vaccination with Alpha-Gal Protects Against Mycobacterial Infection in the Zebrafish Model of Tuberculosis.Vaccines · 2020Article
- Infection withVaccines · 2020Article
- B Cell Responses in the Development of Mammalian Meat Allergy.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
Abstract
Due to the functional inactivation of the gene encoding for the enzyme that is involved in the oligosaccharide galactose-α-1,3-galactose (α-Gal) synthesis, humans and Old-World primates are able to produce a large amount of antibodies against the glycan epitope. Apart from being involved in the hyperacute organ rejection in humans, anti-α-Gal antibodies have shown a protective effect against some pathogenic agents and an implication in the recently recognized tick-induced mammalian meat allergy. Conversely, non-primate mammals, including dogs, have the ability to synthetize α-Gal and, thus, their immune system is not expected to naturally generate the antibodies toward this self-antigen molecule. However, in the current study, we detected specific IgG, IgM, and IgE antibodies to α-Gal in sera of clinically healthy dogs by an indirect enzyme-linked immunosorbent assay (ELISA) for the first time. Furthermore, in a tick infestation experiment, we showed that bites of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.