Evidence map›Paper›PMID 31540063›Full record

ArticleCancers2019

Hyperspectral Imaging of Head and Neck Squamous Cell Carcinoma for Cancer Margin Detection in Surgical Specimens from 102 Patients Using Deep Learning.

Martin Halicek, James D Dormer, James V Little, Amy Y Chen, Larry Myers, Baran D Sumer, Baowei Fei

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 132 citations in OpenAlex.

  1. Pooled it
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  4. Article
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  7. Article
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  11. LED-based, real-time, hyperspectral imaging device.Journal of medical imaging (Bellingham, Wash.) · 2025
    Article
  12. Article
  13. Review
  14. Optimization of Transfer Learning of Foundation Models for Hyperspectral Histologic Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  15. A high-speed hyperspectral imaging system and large-scale hyperspectral dataset for abdominal surgical applications.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  16. Masked image modeling in medical hyperspectral imaging: reconstruction evaluation and downstream tasks.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  17. Article
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  19. Review
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Martin HalicekDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.
James D DormerDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA.ORCID 0000-0002-0719-6697
James V LittleDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Amy Y ChenDepartment of Otolaryngology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Larry MyersDepartment of Otolaryngology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Baran D SumerDepartment of Otolaryngology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Baowei FeiDepartment of Bioengineering, The University of Texas at Dallas, Richardson, TX 75080, USA. bfei@utdallas.edu.
Emory University · USThe University of Texas at Dallas · USThe University of Texas Southwestern Medical Center · USGeorgia Institute of Technology · US

Funding

Foundation for the National Institutes of Health CA176684,CA156775, CA204254,
6 · The paper itself

Abstract

Surgical resection of head and neck (H and N) squamous cell carcinoma (SCC) may yield inadequate surgical cancer margins in 10 to 20% of cases. This study investigates the performance of label-free, reflectance-based hyperspectral imaging (HSI) and autofluorescence imaging for SCC detection at the cancer margin in excised tissue specimens from 102 patients and uses fluorescent dyes for comparison. Fresh surgical specimens (

Indexed as

convolutional neural networkdeep learninghead and neck cancerhyperspectral imagingsquamous cell carcinoma

Identifiers

PMID31540063
PMCPMC6769839
OpenAlexW2973216789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.