Evidence map›Paper›PMID 31540031›Full record

ArticleInternational journal of molecular sciences2019

Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of SVS2 in Male Fertility.

Miyuki Shindo, Masafumi Inui, Woojin Kang, Moe Tamano, Cai Tingwei, Shuji Takada, Taku Hibino, Manabu Yoshida, Kaoru Yoshida, Hiroshi Okada and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Seminal fluid and accessory male investment in sperm competition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Review
  12. Article
  13. Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction.Laboratory investigation; a journal of technical methods and pathology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Miyuki ShindoDivision of Laboratory Animal Resources, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan. shindo-m@ncchd.go.jp.ORCID 0000-0002-3913-4992
Masafumi InuiLaboratory of Animal Regeneration Systemology, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Kawasaki, Kanagawa 214-8571, Japan. inui_m@meiji.ac.jp.ORCID 0000-0003-4720-007X
Woojin KangDepartment of Reproductive Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan. kwjbear@gmail.com.
Moe TamanoDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan. tamanom@adm.h.u-tokyo.ac.jp.
Cai TingweiLaboratory of Regulatory Biology, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Kawasaki, Kanagawa 214-8571, Japan. ef61618@meiji.ac.jp.
Shuji TakadaDepartment of Systems BioMedicine, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan. takada-s@ncchd.go.jp.
Taku HibinoFaculty of Education, Saitama University, 255 Shimo-Okubo, Sakura, Saitama, Saitama 338-8570, Japan. hibino@mail.saitama-u.ac.jp.
Manabu YoshidaMisaki Marine Biological Station, Graduate School of Science, University of Tokyo, 1024 Koajiro, Miura, Kanagawa 238-0225, Japan. yoshida@mmbs.s.u-tokyo.ac.jp.ORCID 0000-0003-4927-868X
Kaoru YoshidaFaculty of Biomedical Engineering, Toin University of Yokohama, 1614 Kurogane, Aoba, Yokohama 225-8503, Japan. yoshidak@toin.ac.jp.
Hiroshi OkadaDepartment of Urology, Dokkyo Medical University Koshigaya Hospital, 2-1-50 Minamikoshigaya, Koshigaya, Saitama 343-8555, Japan. hirooka@dokkyomed.ac.jp.
Teruaki IwamotoDivision of Male Infertility, Center for Human Reproduction, Sanno Hospital, International University of Health and Welfare, 8-10-16 Akasaka, Minato, Tokyo 107-0052, Japan. t4iwa@iuhw.ac.jp.
Kenji MiyadoDepartment of Reproductive Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya, Tokyo 157-8535, Japan. miyado-k@ncchd.go.jp.ORCID 0000-0002-8339-6738
Natsuko KawanoLaboratory of Regulatory Biology, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Kawasaki, Kanagawa 214-8571, Japan. nkawano@meiji.ac.jp.
National Center For Child Health and Development · JPMeiji University · JPDokkyo Medical University Saitama Medical Center · JPInternational University of Health and Welfare · JPSaitama University · JPToin University of Yokohama · JP

Funding

Japan Agency for Medical Research and Development 17930555Japan Society for the Promotion of Science 17K18164Japan Society for the Promotion of Science 19K06474
6 · The paper itself

Abstract

Multiple genes, whose functions or expression are overlapping, compensate for the loss of one gene. A gene cluster in the mouse genome encodes five seminal vesicle proteins (SVS2, SVS3, SVS4, SVS5, and SVS6). These proteins are produced by male rodents and function in formation of the copulatory plug following mating. SVS2 plays an essential role in the successful internal fertilization by protecting the sperm membrane against a uterine immune attack. We hypothesized that the four remaining seminal vesicle proteins (SVPs) of this gene cluster may partially/completely compensate for the deficiency of SVS2. For confirming our hypothesis, we generated mice lacking the entire SVP-encoding gene cluster and compared their fecundity with

Indexed as

AnimalsFemaleFertilityMaleMiceMultigene FamilyReproductionSeminal Vesicle Secretory ProteinsSequence DeletionSpermatozoaUterusSeminal Vesicle Secretory ProteinsSVS2 protein, mouseSVS4 protein, mousedeletiongene clustermale fertilitysemenseminal vesicle proteins

Identifiers

PMID31540031
PMCPMC6769479
OpenAlexW2973195072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.