Evidence map›Paper›PMID 31539516›Full record

ArticleThe American journal of pathology2019

Avian Reticuloendotheliosis Viral Oncogene Related B Regulates Lymphatic Endothelial Cells during Vessel Maturation and Is Required for Lymphatic Vessel Function in Adult Mice.

Qianqian Liang, Li Zhang, Ronald W Wood, Rui-Cheng Ji, Brendan F Boyce, Edward M Schwarz, Yongjun Wang, Lianping Xing

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Qianqian LiangLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Li ZhangLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Ronald W WoodDepartment of Obstetrics and Gynecology, Urology, and Neurobiology and Anatomy, University of Rochester Medical Center, Rochester, New York.
Rui-Cheng JiOita University, Oita, Japan.
Brendan F BoyceDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York.
Edward M SchwarzCenter for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York.
Yongjun WangLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China. Electronic address: 0000002722@shutcm.edu.cn.
Lianping XingDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York; Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York. Electronic address: lianping_xing@urmc.rochester.edu.
University of Rochester Medical Center · USOita University · JPShanghai University of Traditional Chinese Medicine · CN

Funding

Studies on the fate of the OsteoclastR01AR043510 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI BOYCE, BRENDAN F · 1995 to 2025
$8.4M
Study of osteoblast regulation in TNF-mediated bone lossR01AR063650 · NIAMS · UNIVERSITY OF ROCHESTER · PI XING, LIANPING · 2013 to 2016
$1.4M
Protein modification in bone cell regulationR21AR069789 · NIAMS · UNIVERSITY OF ROCHESTER · PI BOECKMAN, ROBERT K, XING, LIANPING · 2016 to 2017
$372k
NIAMS NIH HHS R01 AR043510NIAMS NIH HHS R01 AR063650NIAMS NIH HHS R21 AR069789
6 · The paper itself

Abstract

NF-κB signals through canonical transcription factor p65 (RelA)/p50 and noncanonical avian reticuloendotheliosis viral oncogene related B (RelB)/p52 pathways. The RelA/p50 is involved in basal and inflammatory lymphangiogenesis. However, the role of RelB/p52 in lymphatic vessel biology is unknown. Herein, we investigated changes in lymphatic vessels (LVs) in mice deficient in noncanonical NF-κB signaling and the function of RelB in lymphatic endothelial cells (LECs). LVs were examined in Relb

Indexed as

Cell ProliferationAnimalsApoptosisCell MovementCells, CulturedEndothelial CellsLymphatic VesselsMiceMice, Inbred C57BLMice, KnockoutNF-kappa BSignal TransductionTranscription Factor RelBNF-kappa BRelb protein, mouseTranscription Factor RelB

Identifiers

PMID31539516
PMCPMC6893922
OpenAlexW2973916536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.