Evidence map›Paper›PMID 31539493›Full record

ArticleCell2019

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.

Ya-Cheng Liao, Michael S Fernandopulle, Guozhen Wang, Heejun Choi, Ling Hao, Catherine M Drerup, Rajan Patel, Seema Qamar, Jonathon Nixon-Abell, Yi Shen and 13 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 324 papers.

0numbers the graph read from it
0cells of the map it votes in
324citing papers in PubMed
38.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

324 citing papers in PubMed, 534 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Synaptic Proteostasis in Health and Disease.Journal of neurochemistry · 2026
    Review
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  19. Review
  20. Subcellular localization as a driver of protein function.Nature reviews. Molecular cell biology · 2026
    Review

264 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 3 countries.

Ya-Cheng LiaoHHMI Janelia Research Campus, Ashburn, VA, USA.
Michael S FernandopulleNINDS, NIH, Bethesda, MD, USA.
Guozhen WangCambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0XY, UK.
Heejun ChoiHHMI Janelia Research Campus, Ashburn, VA, USA.
Ling HaoNINDS, NIH, Bethesda, MD, USA.
Catherine M DrerupNICHD, NIH, Bethesda, MD, USA.
Rajan PatelNINDS, NIH, Bethesda, MD, USA.
Seema QamarCambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0XY, UK.
Jonathon Nixon-AbellCambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0XY, UK.
Yi ShenDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
William MeadowsCambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0XY, UK.
Michele VendruscoloDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Tuomas P J KnowlesDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK; Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.
Matthew NelsonNINDS, NIH, Bethesda, MD, USA.
Magdalena A CzekalskaDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Greta MusteikyteDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
Mariam A GachechiladzeNINDS, NIH, Bethesda, MD, USA.
Christina A StephensNINDS, NIH, Bethesda, MD, USA.
H Amalia PasolliHHMI Janelia Research Campus, Ashburn, VA, USA.
Lucy R ForrestNINDS, NIH, Bethesda, MD, USA.
Peter St George-HyslopCambridge Institute for Medical Research, Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0XY, UK; Department of Medicine (Division of Neurology), University of Toronto and University Health Network, Toronto, Ontario M5S 3H2, Canada.
Jennifer Lippincott-SchwartzHHMI Janelia Research Campus, Ashburn, VA, USA. Electronic address: lippincottschwartzj@janelia.hhmi.org.
Michael E WardNINDS, NIH, Bethesda, MD, USA. Electronic address: wardme@nih.gov.
University of Cambridge · GBNational Institutes of Health · USJanelia Research Campus · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity Health Network · CA

Funding

Mechanisms of inherited neurodegenerative diseasesZIANS003155 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI WARD, MICHAEL · 2016 to 2025
$24.7M
Mechanisms of autophagic dysfunction in progranulin-related neurodegenerationF30AG060722 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI FERNANDOPULLE, MICHAEL · 2018 to 2022
$203k
Intramural NIH HHS ZIA NS003155NIA NIH HHS F30 AG060722Wellcome Trust 203249/Z/16/Z
6 · The paper itself

Abstract

Long-distance RNA transport enables local protein synthesis at metabolically-active sites distant from the nucleus. This process ensures an appropriate spatial organization of proteins, vital to polarized cells such as neurons. Here, we present a mechanism for RNA transport in which RNA granules "hitchhike" on moving lysosomes. In vitro biophysical modeling, live-cell microscopy, and unbiased proximity labeling proteomics reveal that annexin A11 (ANXA11), an RNA granule-associated phosphoinositide-binding protein, acts as a molecular tether between RNA granules and lysosomes. ANXA11 possesses an N-terminal low complexity domain, facilitating its phase separation into membraneless RNA granules, and a C-terminal membrane binding domain, enabling interactions with lysosomes. RNA granule transport requires ANXA11, and amyotrophic lateral sclerosis (ALS)-associated mutations in ANXA11 impair RNA granule transport by disrupting their interactions with lysosomes. Thus, ANXA11 mediates neuronal RNA transport by tethering RNA granules to actively-transported lysosomes, performing a critical cellular function that is disrupted in ALS.

Indexed as

Amyotrophic Lateral SclerosisAnimalsAnimals, Genetically ModifiedAnnexinsAxonal TransportAxonsCell Line, TumorCytoplasmic GranulesFemaleHumansInduced Pluripotent Stem CellsLysosomesMaleMutationProtein BindingRatsAnnexinsRNAAmyotrophic lateral sclerosisANXA11Local translationLysosomeNeurodegenerationNeuronOrganelles contactPhase separationRNA granuleRNA transport

Identifiers

PMID31539493
PMCPMC6890474
OpenAlexW2973356406

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.