ArticlePloS one2019
Time-related immunomodulation by stressors and corticosterone transdermal application in toads.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 41 citations in OpenAlex.
- Introduction to the special issue Amphibian immunity: stress, disease and ecoimmunology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Contrasting effects of transdermal and implant corticosterone treatments in the American bullfrog wound healing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Testosterone immunomodulation in free-living and captivePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Critical review of the phytohemagglutinin assay for assessing amphibian immunity.Conservation physiology · 2023Article
- Comparison of Corticosterone Concentrations in Dermal Secretions and Urine in Free-Ranging Marine Toads (Veterinary medicine international · 2023Article
- Stress Response, Immunity, and Organ Mass in Toads (Rhinella diptycha) Living in Metal-Contaminated Areas.Biological trace element research · 2022Article
- Stress in paradise: effects of elevated corticosterone on immunity and avian malaria resilience in a Hawaiian passerine.The Journal of experimental biology · 2021Article
- Short-term stressors and corticosterone effects on immunity in male toads (Brain, behavior, & immunity - health · 2021Article
- Hybrid LPG-FBG Based High-Resolution Micro Bending Strain Sensor.Sensors (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune responses have been mostly studied at a specific time in anuran species. However, time-changes related to immunomodulation associated with glucocorticoid (GC) alterations following stressors and GC treatment are complex. The present study describes time-related changes in immune response and corticosterone (CORT) plasma levels following restraint challenge, short, mid and long-term captivity, and CORT exogenous administration by transdermal application (TA) in Rhinella ornata toads. We observed increased neutrophil: lymphocyte ratios after restraint challenge and CORT TA, without changes following short and mid-term captivity. Plasma bacterial killing ability was sustained in all treatments, except long-term captivity, with decreased values after 90 days under such conditions. Phagocytic activity of peritoneal cells increased after mid-term captivity, and the phytohemagglutinin swelling response was impaired in those animals treated with CORT TA for 20 consecutive days. Plasma CORT levels increased or were sustained after restraint challenge (depending on initial values), decreased following mid and long-term captivity (for those animals showing high CORT in the field) and increased after 20 days of CORT TA. By performing assessments of time-changes in immune processes and CORT plasma levels in R. ornata, we demonstrate immuno-enhancing effects following restraint, short and mid-term stressors, while long-term stressors and CORT TA promoted immunosuppression in these toads.
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