ArticlePLoS neglected tropical diseases2019
Human granulocytic anaplasmosis in Kinmen, an offshore island of Taiwan.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Human granulocytotropic anaplasmosis-A systematic review and analysis of the literature.PLoS neglected tropical diseases · 2024Pooled it
- The first direct detection of spotted fever group Rickettsia spp. diversity in ticks from Ningxia, northwestern China.PLoS neglected tropical diseases · 2025Article
- Molecular epidemiology and genetic diversity of Anaplasma and Theileria spp. in Pakistani sheep.PloS one · 2025Article
- Economic impact of patients with medical evacuation in remote islands: a case study in Matsu Islands.Frontiers in public health · 2025Article
- The Prevalence ofChina CDC weekly · 2024Article
- Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia.BMC microbiology · 2023Article
- Molecular Survey of Vector-Borne Pathogens in Ticks, Sheep Keds, and Domestic Animals from Ngawa, Southwest China.Pathogens (Basel, Switzerland) · 2022Article
- Parasitic and Vector-Borne Infections in HIV-Positive Patients in Slovakia-Evidence of an Unexpectedly High Occurrence ofPathogens (Basel, Switzerland) · 2021Article
- Seroepidemiological Study of Spotted Fever Group Rickettsiae and Identification of a Putative New Species,Pathogens (Basel, Switzerland) · 2021Article
- Neglected human Rickettsia felis infection in Taiwan: A retrospective seroepidemiological survey of patients with suspected rickettsioses.PLoS neglected tropical diseases · 2021Article
- The absence of the drhm gene is not a marker for human-pathogenicity in European Anaplasma phagocytophilum strains.Parasites & vectors · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman granulocytic anaplasmosis, a tick-borne infection caused by Anaplasma phagocytophilum, has received scant attention, while scrub typhus, a mite-transmitted disease caused by Orientia tsutsugamushi, is the most common rickettsiosis in Taiwan. The clinical presentations of both diseases are characterized by undifferentiated fever, headache and malaise. Moreover, both pathogens have been detected in small mammals that serve as hosts for chiggers and ticks in the wild. The objective of the present study was to investigate whether human granulocytic anaplasmosis occurs in Taiwan. METHODOLOGY/PRINCIPAL
findingsBlood samples from 274 patients suspected of having scrub typhus in Kinmen, an offshore island of Taiwan, in 2011 and 2012 were retrospectively examined by immunofluorescence assays. IgG antibodies reactive with Anaplasma phagocytophilum was found in 31.8% (87/274) of the patients. Paired serology identified 3 patients with human granulocytic anaplasmosis and 8 patients with coinfection with O. tsutsugamushi and A. phagocytophilum. Laboratory tests showed that elevated serum ALT/AST, creatinine, and BUN levels were observed in patients with anaplasmosis and coinfection, but elevated serum CRP levels, thrombocytopenia, and anemia were only observed in coinfected patients. PCR detected A. phagocytophilum 16S rDNA and p44/msp2 in 2 patients. The phylogenetic analysis suggested that the replicons of the 16S rDNA shared high sequence similarity with the reference sequences in the Korea, USA, Japan, and China. The amplicons of p44/msp2 were close to those of the human variants identified in the USA and Japan.
conclusionsOur findings indicated that A. phagocytophilum infection was prevalent but unrecognized in Taiwan.
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