ArticleAngewandte Chemie (International ed. in English)2019
A Chalcogen-Bonding Cascade Switch for Planarizable Push-Pull Probes.
Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Visible light-induced single bond rotation in azoarenes triggered by self-sensitized oxidation.Chemical science · 2026Article
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- Substituent Effects in Tetrel Bonds Involving Aromatic Silane Derivatives: An ab initio Study.Molecules (Basel, Switzerland) · 2023Article
- Dynamic Covalent Michael Acceptors to Penetrate Cells: Thiol-Mediated Uptake with Tetrel-Centered Exchange Cascades, Assisted by Halogen-Bonding Switches.Angewandte Chemie (International ed. in English) · 2022Article
- Dithieno[3,2-RSC advances · 2022Review
- Noncovalent Interactions Involving Group 6 in Biological Systems: The Case of Molybdopterin and Tungstopterin Cofactors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Cyclic Thiosulfonates for Thiol-Mediated Uptake: Cascade Exchangers, Transporters, Inhibitors.JACS Au · 2022Article
- HydroFlipper membrane tension probes: imaging membrane hydration and mechanical compression simultaneously in living cells.Chemical science · 2022Article
- Computational Evaluation of MeChemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Article
- DFT and IsoStar Analyses to Assess the Utility of σ- and π-Hole Interactions for Crystal Engineering.Chemphyschem : a European journal of chemical physics and physical chemistry · 2021Article
- Substituent-Controlled Tailoring of Chalcogen-Bonded Supramolecular Nanoribbons in the Solid State.Crystal growth & design · 2021Article
- HaloFlippers: A General Tool for the Fluorescence Imaging of Precisely Localized Membrane Tension Changes in Living Cells.ACS central science · 2020Article
- Engineering Crystals Using spChemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Noble Gas Bonding Interactions Involving Xenon Oxides and Fluorides.Molecules (Basel, Switzerland) · 2020Review
- Twisting and tilting of a mechanosensitive molecular probe detects order in membranes.Chemical science · 2020Article
- Methyl Scanning for Mechanochemical Chalcogen-Bonding Cascade Switches.ChemistryOpen · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Planarizable push-pull probes have been introduced to demonstrate physical forces in biology. However, the donors and acceptors needed to polarize mechanically planarized probes are incompatible with their twisted resting state. The objective of this study was to overcome this "flipper dilemma" with chalcogen-bonding cascade switches that turn on donors and acceptors only in response to mechanical planarization of the probe. This concept is explored by molecular dynamics simulations as well as chemical double-mutant cycle analysis. Cascade switched flipper probes turn out to excel with chemical stability, red shifts adding up to high significance, and focused mechanosensitivity. Most important, however, is the introduction of a new, general and fundamental concept that operates with non-trivial supramolecular chemistry, solves an important practical problem and opens a wide chemical space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.