Evidence map›Paper›PMID 31538749›Full record

ArticleCancer medicine2019

Isolation and characterization of spontaneously immortalized B-lymphocyte lines from HIV-infected patients with and without non-Hodgkin's Lymphoma.

Ke Zhuang, Yongxi Zhang, Li Zhou, Xiaoying Qi, Xiqiu Xu, Fengzhen Meng, Zhigao Xu, Jinbiao Liu, Liang Shao, Huan Liu and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Ke ZhuangABSL-III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan, China.ORCID 0000-0003-3471-969X
Yongxi ZhangDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Li ZhouABSL-III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan, China.
Xiaoying QiDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xiqiu XuBasic Medical College of Wuhan University, Wuhan, China.
Fengzhen MengBasic Medical College of Wuhan University, Wuhan, China.
Zhigao XuDepartment of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jinbiao LiuABSL-III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan, China.
Liang ShaoDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Huan LiuDepartment of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Hang LiuBasic Medical College of Wuhan University, Wuhan, China.
Jun FangAIDS Institute and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Di DengDepartment of Radiation Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Jianhong PengDepartment of Clinical Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Fuling ZhouDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Li LiuAIDS Institute and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Hongbin TangABSL-III Laboratory at the Center for Animal Experiment, State Key Laboratory of Virology, Wuhan University, Wuhan, China.
Yong XiongDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wenzhe HoBasic Medical College of Wuhan University, Wuhan, China.
Deying GuoSchool of Basic Medicine (Shenzhen), Sun Yat-sen University, Guangdong, China.
Hengning KeDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xien GuiDepartment of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China.
Wuhan University · CNChinese University of Hong Kong · HKSun Yat-sen University · CN

Funding

Fundamental Research Funds for the Central Universities 2042016kf0186Fundamental Research Funds for the Health and Family Planning Commission of Hubei Province WJ2017M010National Natural Science Foundation of China 81301428National Natural Science Foundation of China 81471943National Natural Science Foundation of China 81670069
6 · The paper itself

Abstract

Isolation of viable circulating tumor cells (CTC) holds the promise for improving screening, early diagnosis, and personalized treatment of lymphoma. In this study, we isolated and characterized spontaneously immortalized B-lymphocyte (SIBC) lines from HIV-infected patients with and without Non-Hodgkin's Lymphoma (AIDS-NHL). A total of 22 SIBC lines was isolated from peripheral blood mononuclear cells (PBMC) of HIV-infected patients with (n = 40) and without (n = 77) clinically detectable NHL, but not from healthy individuals (n = 34). Of these, 8 SIBC lines named HIV-SIBC were generated from HIV-infected patients without AIDS-NHL (10%, 8/77), while 14 SIBCs named AIDS-NHL-SIBC were from 13 of the AIDS-NHL patients (32.5%, 13/40). Among the 14 AIDS-NHL-SIBCs, 12 were derived from AIDS-NHL patients with poor prognoses (survival time less than 1 year). SIBCs displayed markers typical of memory B cells (CD3

Indexed as

AdolescentAdultAgedAnimalsB-LymphocytesCase-Control StudiesCell SeparationComorbidityFemaleHIV InfectionsHumansLymphoma, Non-HodgkinMaleMiddle AgedNeoplasm StagingNeoplasm TransplantationB-lymphocyteHIV infectionimmortalizedNHLspontaneous

Identifiers

PMID31538749
PMCPMC6825990
OpenAlexW3002974945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.