Evidence map›Paper›PMID 31538643›Full record

Observational studyClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Oseltamivir Resistance in Severe Influenza A(H1N1)pdm09 Pneumonia and Acute Respiratory Distress Syndrome: A French Multicenter Observational Cohort Study.

Sylvie Behillil, Faten May, Slim Fourati, Charles-Edouard Luyt, Thomas Chicheportiche, Romain Sonneville, Yacine Tandjaoui-Lambiotte, Damien Roux, Laurent Guérin, Julien Mayaux and 8 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Article
  7. An anti-complement homogeneous polysaccharide fromActa pharmaceutica Sinica. B · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Influenza Therapeutics in Clinical Practice-Challenges and Recent Advances.Cold Spring Harbor perspectives in medicine · 2021
    Review
  13. A global treatments for coronaviruses including COVID-19.Journal of cellular physiology · 2020
    Review
  14. Article
  15. Review
  16. Investigation of HumanFrontiers in cellular and infection microbiology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Sylvie BehillilUnité de Génétique Moléculaire des Virus à ARN et Centre National de Référence des Virus des Infections Respiratoires (Dont la Grippe), Institut Pasteur, UMR3569 CNRS, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Faten MayService de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Slim FouratiDépartement de Microbiologie, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Charles-Edouard LuytService de Médecine Intensive Réanimation, Hôpital de La Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
Thomas ChicheporticheService de Médecine Intensive Réanimation, Hôpital de La Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
Romain SonnevilleService de Médecine Intensive Réanimation, Hôpital Bichat Claude Bernard, Assistance Publique Hôpitaux de Paris, Paris, France.
Yacine Tandjaoui-LambiotteService de Réanimation Médico-Chirurgicale, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
Damien RouxService de Réanimation Médico Chirurgicale, Hôpital Louis Mourier, Assistance Publique-Hôpitaux de Paris, Colombes, INSERM UMR1137, IAME, Université Paris Diderot, Paris, France.
Laurent GuérinService de Réanimation Médicale, Hôpital Bicètre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicètre, France.
Julien MayauxService de Réanimation Médicale et Pneumologie, Hôpital de La Pitié Salpétrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
Eric MauryService de Réanimation Médicale, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris, France.
Alexis FerréService de Réanimation, Centre Hospitalier de Versailles, Le Chesnay, France.
Jean-François GeorgerService de Réanimation, Centre Hospitalier Intercommunal de Villeneuve Saint-Georges, Villeneuve Saint-Georges, France.
Guillaume VoiriotService de Réanimation Médicale, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France.
Vincent EnoufUnité de Génétique Moléculaire des Virus à ARN et Centre National de Référence des Virus des Infections Respiratoires (Dont la Grippe), Institut Pasteur, UMR3569 CNRS, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Sylvie van der WerfUnité de Génétique Moléculaire des Virus à ARN et Centre National de Référence des Virus des Infections Respiratoires (Dont la Grippe), Institut Pasteur, UMR3569 CNRS, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Armand Mekontso DessapService de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France.
Nicolas de ProstService de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a multicenter cohort study including 22 oseltamivir-treated patients with influenza A(H1N1)pdm09 acute respiratory distress syndrome, prevalence of the H275Y substitution in the neuraminidase, responsible for highly reduced sensitivity to oseltamivir, was 23%. Patients infected with the H275Y mutant virus had higher day 28 mortality than others (80% vs 12%; P = .011).

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza, HumanPneumoniaRespiratory Distress SyndromeAntiviral AgentsCohort StudiesDrug Resistance, ViralHumansNeuraminidaseOseltamivirAntiviral AgentsNeuraminidaseOseltamiviradultH1N1 subtypeinfluenza A virusoseltamivirpneumoniarespiratory distress syndromeviral

Identifiers

PMID31538643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.