ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019
The Association Between Obstructive Sleep Apnea Characterized by a Minimum 3 Percent Oxygen Desaturation or Arousal Hypopnea Definition and Hypertension.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Association of obstructive sleep apnoea with long-term cardiovascular events in patients with acute coronary syndrome with or without hypertension: insight from the OSA-ACS project.BMJ open respiratory research · 2023Trial
- Socioeconomic status impacts blood pressure response to positive airway pressure treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- Parapharyngeal Fat Pads as an Obesity-Related Parameter for Apnea-Hypopnea Index Severity.Journal of sleep research · 2026Article
- The relationship between vertigo severity, psychiatric symptoms and obstructive sleep apnoea.Journal of otology · 2026Article
- Effects of daylight savings time transition on compliance and effectiveness of positive airway pressure therapy.Sleep and biological rhythms · 2025Article
- Article
- Condylar Position in the Treatment of Obstructive Sleep Apnea with a Mandibular Advancement Device: A Pilot Study.Sleep science (Sao Paulo, Brazil) · 2023Article
- Breathing cessation events that compose the apnea-hypopnea index are distinctively associated with the adverse outcomes in Alzheimer's disease.Alzheimer's research & therapy · 2023Observational
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- A Prospective Study on Obstructive Sleep Apnea, Clinical Profile and Polysomnographic Variables.Journal of personalized medicine · 2023Article
- Benchmarking performance of an automatic polysomnography scoring system in a population with suspected sleep disorders.Frontiers in neurology · 2023Article
- Sleepiness in obstructive sleep apnea using hypopneas defined by a 3% oxygen desaturation or arousal but not by 4% or greater oxygen desaturation.Sleep & breathing = Schlaf & Atmung · 2022Article
- A transition to the American Academy of Sleep Medicine-recommended hypopnea definition in adults: initiatives of the Hypopnea Scoring Rule Task Force.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Development and validation of a clinical model to predict hypertension in consecutive patients with obstructive sleep apnea hypopnea syndrome: a hospital-based study and nomogram analysis.American journal of translational research · 2022Article
- Obstructive Sleep Apnea in Pregnancy: Early Lessons From Our Sleep Pregnancy Clinic.WMJ : official publication of the State Medical Society of Wisconsin · 2021Article
- Long-term All-Cause Mortality Risk in Obstructive Sleep Apnea Using Hypopneas Defined by a ≥3 Percent Oxygen Desaturation or Arousal.Southwest journal of pulmonary & critical care · 2021Article
- Incidence of hypertension in obstructive sleep apnea using hypopneas defined by 3 percent oxygen desaturation or arousal but not by only 4 percent oxygen desaturation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- What are we missing? Hypertension and hypopneas.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Prevalence and correlates of obstructive sleep apnea in urban-dwelling, low-income, predominantly African-American women.Sleep medicine · 2020Article
- Hypopneas with arousals: an important feature of central nervous system sympathetic activation in posttraumatic stress disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
STUDY
objectivesThe association between obstructive sleep apnea (OSA) and hypertension in prior studies has been determined using a definition of hypopnea requiring a 4% O₂ desaturation. However, the American Academy of Sleep Medicine (AASM) recommends using a 3% O₂ desaturation or an arousal. This analysis assesses the relationship between OSA and hypertension utilizing the AASM recommended definition and the 2018 American College of Cardiology/American Heart Association hypertension guidelines.
methodsData from 6113 participants from the Sleep Heart Health Study were analyzed. The AASM recommended apnea-hypopnea index (AHI) was classified into 4 categories of OSA severity: < 5, 5 to < 15, 15 to < 30 and ≥ 30 events/h. Three definitions of hypertension were used: elevated (> 120/< 80 or use of hypertension medications [meds]), stage 1/stage 2 (> 130/80 or meds), stage 2 (> 140/90 or meds). Data were analyzed using logistic regression controlling for demographics, smoking and body mass index. Multiple linear regression analysis assessed the relationship between natural log AHI, and systolic and diastolic blood pressure controlling for the same covariates.
resultsFor all definitions of blood pressure elevation, increasing OSA severity was associated with greater likelihood of an elevated or hypertensive status in fully adjusted models (odds ratio [95% confidence interval]): elevated 1.30 (1.09-1.54), 1.39 (1.13-1.70) 1.69 (1.29-2.13); stage 1/2: 1.25 (1.06-1.47), 1.32 (1.10-1.59), 1.53 (1.23-1.91); stage 2: 1.07 (0.91-1.25), 1.21 (1.01-1.44), 1.37 (1.11-1.69) for AHI 5 to < 15, 15 to < 30 and > 30 events/h (< 5 events/h reference). Linear regression found that AHI was associated with both systolic and diastolic blood pressure in fully adjusted models.
conclusionsUse of the AASM recommended definition of hypopnea as a component of the AHI is associated with the presence of hypertension. CITATION: Budhiraja R, Javaheri S, Parthasarathy S, Berry RB, Quan SF. The association between obstructive sleep apnea characterized by a minimum 3 percent oxygen desaturation or arousal hypopnea definition and hypertension. J Clin Sleep Med. 2019;15(9):1261-1270.
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