ArticleEmerging infectious diseases2019
VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy.
Article in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- SARS-CoV-2 seroprevalence among Beninese pregnant women in the third year of the pandemic.BMC public health · 2024Article
- IgG and IgM responses to the Plasmodium falciparum asexual stage antigens reflect respectively protection against malaria during pregnancy and infanthood.Malaria journal · 2024Article
- Molecular tools are crucial for malaria elimination.Molecular biology reports · 2024Review
- Detecting temporal and spatial malaria patterns from first antenatal care visits.Nature communications · 2023Article
- Detecting temporal and spatial malaria patterns from first antenatal care visits.Research square · 2023Article
- Anti-phosphatidylserine antibody levels are low in multigravid pregnant women in a malaria-endemic area in Nigeria, and do not correlate with anti-VAR2CSA antibodies.Frontiers in cellular and infection microbiology · 2023Article
- Gravidity and malaria trends interact to modify P. falciparum densities and detectability in pregnancy: a 3-year prospective multi-site observational study.BMC medicine · 2022Observational
- Quantification of the dynamics of antibody response to malaria to inform sero-surveillance in pregnant women.Malaria journal · 2022Article
- Naturally Acquired Antibodies againstPathogens (Basel, Switzerland) · 2021Review
- Article
- Diagnosis & management of imported malaria in pregnant women in non-endemic countries.The Indian journal of medical research · 2020Review
- Targeting Pregnant Women for Malaria Surveillance.Trends in parasitology · 2019Review
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Authors and funding
32 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We used a multiplex peptide-based suspension array in 2,354 samples from pregnant women from Mozambique, Benin, Kenya, Gabon, Tanzania, and Spain. Two VAR2CSA peptides of limited polymorphism were immunogenic and targeted by IgG responses readily boosted during infection and with estimated half-lives of <2 years. Seroprevalence against these peptides reflected declines and rebounds of transmission in southern Mozambique during 2004-2012, reduced exposure associated with use of preventive measures during pregnancy, and local clusters of transmission that were missed by detection of P. falciparum infections. These data suggest that VAR2CSA serology can provide a useful adjunct for the fine-scale estimation of the malaria burden among pregnant women over time and space.
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