Evidence map›Paper›PMID 31538289›Full record

Trial reportAnnals of surgical oncology2020

Predictors and Prevalence of Nodal Disease in Salvage Oropharyngectomy.

M E Heft Neal, J Brennan, J C Brenner, A G Shuman, S B Chinn, C L Stucken, K M Malloy, J S Moyer, K A Casper, S A McLean and 6 more

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Upfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV+ OPSCC.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Trial
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

M E Heft NealDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
J BrennanDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
J C BrennerDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
A G ShumanDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
S B ChinnDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
C L StuckenDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
K M MalloyDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
J S MoyerDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
K A CasperDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
S A McLeanDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
M E P PrinceDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
C R BradfordDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
G T WolfDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
D B ChepehaHead and Neck Surgical Oncology and Reconstructive Microsurgery, Department of Otolaryngology, Department of Surgical Oncology, University of Toronto, Toronto, ON, USA.
A J RoskoDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA.
M E SpectorDepartment of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, MI, USA. mspector@med.umich.edu.
Michigan Medicine · US

Funding

Advanced Research Training in OtolaryngologyT32DC005356 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORFAS, GABRIEL · 2002 to 2021
$3.5M
NIDCD NIH HHS T32 DC005356
6 · The paper itself

Abstract

backgroundPatients with recurrent oropharyngeal cancer often require extensive salvage surgery. For patients with clinically N0 necks, the indication for concurrent neck dissection remains unclear. This study aimed to determine predictors, prevalence, and distribution of nodal disease in patients treated with salvage oropharyngectomy.

methodsIn a case series with data collection at a single tertiary academic National Cancer Institute (NCI)-designated comprehensive cancer center, this study analyzed patients treated with prior radiation or chemoradiation who had persistent, recurrent, or second primary squamous cell carcinoma of the oropharynx requiring oropharyngeal resection between 1998 and 2017 (n = 95). Clinical and oncologic characteristics and treatment outcomes were collected, and statistical analyses were performed.

resultsThe overall rate of nodal positivity was 21% (24/95), and the rate of occult nodal disease was 6% (4/65). Ipsilateral and contralateral level 2 were the most common areas harboring positive nodes. Bivariate analysis showed female sex (p = 0.01), initial overall stage (p = 0.02), and N status (p = 0.03), as well as recurrent overall and T stage (p = 0.05) to be predictors of nodal disease. In the multivariate analysis, recurrent T stage continued to be significantly predictive of pathologic nodal disease. Both computed tomography (CT) and positron emission tomography-CT were moderately accurate in predicting nodal disease in the salvage setting (area under the curve, 0.79 and 0.80, respectively).

conclusionOccult nodal disease is observed in few patients undergoing salvage oropharyngeal resection. This study identified factors predictive of nodal disease in patients undergoing salvage oropharyngectomy and appropriate diagnostic tests in this setting.

Indexed as

CanadaCarcinoma, Squamous CellFemaleFollow-Up StudiesHumansLymphatic DiseasesLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm Recurrence, LocalOropharyngeal NeoplasmsPharyngectomyPrevalencePrognosisRetrospective Studies

Identifiers

PMID31538289
PMCPMC7135945
OpenAlexW2974904054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.