Evidence map›Paper›PMID 31538282›Full record

ArticleJournal of pharmacokinetics and pharmacodynamics2019

A modeling and simulation-based assessment of the impact of confounding factors on the readout of a sildenafil survival trial in pulmonary arterial hypertension.

Pascal Chanu, Xiang Gao, Rene Bruno, Laurent Claret, Lutz Harnisch

Abstract readClinical Trial Protocol
PubMed Publisher
In one paragraph

Article in Journal of pharmacokinetics and pharmacodynamics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

Pascal ChanuClinical Pharmacology, Genentech/Roche, Lyon, France.
Xiang GaoAlexion Pharmaceuticals, Pharmacometrics and Physiological PK/PD Modeling and Simulation, Cheshire, CT, USA.
Rene BrunoClinical Pharmacology, Genentech/Roche, Marseille, France.
Laurent ClaretClinical Pharmacology, Genentech/Roche, Marseille, France.
Lutz HarnischPfizer, Pharmacometrics/Global Clinical Pharmacology, Sandwich, UK. Lutz.O.Harnisch@pfizer.com.
Roche (France) · FRAlexion Pharmaceuticals (United States) · USPfizer (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sildenafil (REVATIO

Indexed as

Models, BiologicalAdultClinical Trials as TopicComputer SimulationConfounding Factors, EpidemiologicFemaleHumansMalePulmonary Arterial HypertensionRisk FactorsSildenafil CitrateSurvival AnalysisTime FactorsTreatment OutcomeYoung AdultSildenafil CitrateClinical trial simulationsConfoundingPulmonary arterial hypertensionSurvival

Identifiers

PMID31538282
OpenAlexW2974769038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.