ArticleMycopathologia2020
Whole-genome resequencing of Trichophyton rubrum provides insights into population differentiation and drug resistance.
Article in Mycopathologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinical Characteristics, Antimicrobial Resistance Profiles and Carbapenemases Genotypes ofInfection and drug resistance · 2026Article
- ARTP mutagenesis for genome-wide identification of genes important for biofilm regulation in spoilage bacteriumApplied and environmental microbiology · 2025Article
- Insights into Changing Dermatophyte Spectrum in India Through Analysis of Cumulative 161,245 Cases Between 1939 and 2021.Mycopathologia · 2023Article
- The Transcriptional Regulation of Genes Involved in the Immune Innate Response of Keratinocytes Co-Cultured withJournal of fungi (Basel, Switzerland) · 2022Article
- Anti-dermatophytic activity of cold atmospheric plasma against Trichophyton rubrum via affecting fungal growth, morphology, drug susceptibility and HSP90 gene expression.Scientific reports · 2022Article
- Genome-wide identification and functional analysis of circRNAs in Trichophyton rubrum conidial and mycelial stages.BMC genomics · 2022Article
- Proteome-Wide Identification and Functional Analysis of Lysine Crotonylation inFrontiers in genetics · 2022Article
- Founder Effects Contribute to the Population Genetic Structure of the Major Dermatophytosis PathogenClinical, cosmetic and investigational dermatology · 2021Article
- Onygenalean Fungi as Major Human and Animal Pathogens.Mycopathologia · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Trichophyton rubrum (T. rubrum) is anthropophilic fungus and thus a very common cause of dermatophyte infections around the world. Infection of T. rubrum could result in conditions such as tinea capitis, tinea corporis, tinea inguinalis, tinea manus, tinea unguium, or tinea pedis. Because of this, the resistance of T. rubrum to antifungal therapies has drawn extensive research interest. However, the pathogenic characteristics of T. rubrum, such as site of infections, geographic location and host groups, have yet to be explored. In this study, the whole genome of 48 strains from different regions is resequenced and the population structure and association of single nucleotide polymorphism with resistance to six widely used antifungal drugs are analyzed. A total of 23,394 genomic variations are detected, which cover 2165 genes with only 15.14% of the variations located in exons. The population structure of T. rubrum is monomorphic, and genetic diversity is very low. Population structure analysis shows that the 48 sampled strains can be divided into two sub-populations. The gene TERG_08771 harboring the highest SNPs density is found to be associated with resistance to voriconazole. Although many proteins have yet to be identified and explored, association studies could still be useful to identify drug resistance or drug-susceptible loci, which would warrant further insightful investigations.
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