ArticleCrystal growth & design2017
Influence of Chemical Functionality on the Rate of Polymer-Induced Heteronucleation.
Article in Crystal growth & design, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Electron donor-acceptor hybrid bonding polymers exhibit symmetry breaking and ferroelectricity.Journal of materials chemistry. C · 2026Article
- Stimuli-Responsive Star Polymer as an Admixture for Crystallization of Hollow Crystals.Materials (Basel, Switzerland) · 2022Article
- Review
- Role of Self-Assembled Surface Functionalization on Nucleation Kinetics and Oriented Crystallization of a Small-Molecule Drug: Batch and Thin-Film Growth of Aspirin as a Case Study.ACS applied materials & interfaces · 2021Article
- Effect of Polymer Hydrophobicity on the Stability of Amorphous Solid Dispersions and Supersaturated Solutions of a Hydrophobic Pharmaceutical.Molecular pharmaceutics · 2019Article
- The role of molecular modelling and simulation in the discovery and deployment of metal-organic frameworks for gas storage and separation.Molecular simulation · 2019Article
- Probing the Interplay between Amorphous Solid Dispersion Stability and Polymer Functionality.Molecular pharmaceutics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Polymer-induced heteronucleation can dramatically increase the nucleation rate of pharmaceuticals. However, directly comparing the heteronucleation rates of different polymer functionalities is often convoluted with changing physical or structural aspects of heteronuclei. Here, we report a methodology for comparing nucleation efficiencies of different functionalities on polymer heteronuclei of uniform topology with the goal of identifying those functionalities that best accelerate nucleation of a model pharmaceutical. It was found that the previously employed design for additives to speed acetaminophen crystallization underperforms a modified framework that accounts for the effect of competitive solvent binding. These findings are informed by a survey of interactions from the CSD and not only serve to aid in the controlled crystallization of pharmaceuticals, but also provide insight into the mechanism of heteronucleation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.